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rdf:type |
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lifeskim:mentions |
umls-concept:C0012854,
umls-concept:C0039194,
umls-concept:C0042769,
umls-concept:C0085295,
umls-concept:C0205322,
umls-concept:C0332206,
umls-concept:C0449297,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2349975,
umls-concept:C2911692
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pubmed:issue |
3
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pubmed:dateCreated |
2008-3-18
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pubmed:abstractText |
Therapeutic vaccination is a potentially powerful strategy to establish immune control and eradicate persistent viral infections. Large and multifunctional antiviral T cell responses are associated with control of viral persistence; however, for reasons that were mostly unclear, current therapeutic vaccination approaches to restore T cell immunity and control viral infection have been ineffective. Herein, we confirmed that neutralization of the immunosuppressive factor interleukin (IL)-10 stimulated T cell responses and improved control of established persistent lymphocytic choriomeningitis virus (LCMV) infection. Importantly, blockade of IL-10 also allowed an otherwise ineffective therapeutic DNA vaccine to further stimulate antiviral immunity, thereby increasing T cell responses and enhancing clearance of persistent LCMV replication. We therefore propose that a reason that current therapeutic vaccination strategies fail to resurrect/sustain T cell responses is because they do not alleviate the immunosuppressive environment. Consequently, blocking key suppressive factors could render ineffective vaccines more efficient at improving T cell immunity, and thereby allow immune-mediated control of persistent viral infection.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18332180-10395868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18332180-11121048,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18332180-11818468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18332180-12663797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18332180-14991072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18332180-15059848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18332180-15247470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18332180-15487943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18332180-15994790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18332180-16006191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18332180-16025119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18332180-16051844,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18332180-16382236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18332180-16551249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18332180-16710479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18332180-16824070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18332180-16940525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18332180-17030951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18332180-17041596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18332180-17336072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18332180-18332181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18332180-6332167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18332180-7884923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18332180-8113410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18332180-8627058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18332180-8707283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18332180-8837611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18332180-9348305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18332180-9485218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18332180-9565631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18332180-9858507
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1540-9538
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
17
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pubmed:volume |
205
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
533-41
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18332180-Animals,
pubmed-meshheading:18332180-Arenaviridae Infections,
pubmed-meshheading:18332180-Immunosuppression,
pubmed-meshheading:18332180-Interleukin-10,
pubmed-meshheading:18332180-Lymphocytic choriomeningitis virus,
pubmed-meshheading:18332180-Mice,
pubmed-meshheading:18332180-Mice, Inbred C57BL,
pubmed-meshheading:18332180-Mice, Transgenic,
pubmed-meshheading:18332180-Receptors, Interleukin-10,
pubmed-meshheading:18332180-T-Lymphocytes,
pubmed-meshheading:18332180-Vaccination,
pubmed-meshheading:18332180-Vaccines, DNA,
pubmed-meshheading:18332180-Viral Vaccines
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pubmed:year |
2008
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pubmed:articleTitle |
IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection.
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pubmed:affiliation |
Viral-Immunobiology Laboratory, Department of Molecular and Integrative Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA. dbrooks@scripps.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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