|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2008-3-27
|
|
pubmed:abstractText |
Recent clinical observations reported the occurrence of amino acid substitutions at position 181 of the HBV polymerase, associated with a viral breakthrough under lamivudine or adefovir therapy. In this study, we characterized the main variants harboring the rtA181T/V mutation isolated from 10 consecutive patients who developed lamivudine and/or adefovir resistance.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0168-8278
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
48
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
747-55
|
|
pubmed:meshHeading |
pubmed-meshheading:18331765-Adenine,
pubmed-meshheading:18331765-Amino Acid Sequence,
pubmed-meshheading:18331765-DNA, Viral,
pubmed-meshheading:18331765-Drug Resistance, Viral,
pubmed-meshheading:18331765-Hepatitis B,
pubmed-meshheading:18331765-Hepatitis B virus,
pubmed-meshheading:18331765-Humans,
pubmed-meshheading:18331765-Lamivudine,
pubmed-meshheading:18331765-Molecular Sequence Data,
pubmed-meshheading:18331765-Mutation,
pubmed-meshheading:18331765-Phosphonic Acids,
pubmed-meshheading:18331765-RNA-Directed DNA Polymerase,
pubmed-meshheading:18331765-Treatment Failure
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Impact of hepatitis B virus rtA181V/T mutants on hepatitis B treatment failure.
|
|
pubmed:affiliation |
INSERM U871, Laboratoire des virus hépatiques et pathologies associées, 151 cours Albert Thomas, Lyon cedex 03, France.
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
