Linked Life Data

18331361

Source:http://linkedlifedata.com/resource/pubmed/id/18331361

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-4-10
pubmed:abstractText
Understanding the normal functioning of the human lens and its role in the development of disorders of vision, such as presbyopia and cataract, requires a thorough knowledge of how the lens grows and how its properties change with age. Many of these properties can be obtained only by studying the isolated organ in vitro. In addition, because of the difficulties in obtaining human tissues, animal lenses are frequently used as models for the human lens. Information is needed for these as well. In this review, current knowledge of lens growth and factors that affect growth are examined in a variety of species. Topics covered include changes in lens weight, dimensions, stiffness and refractive index distribution with age and the influence of other factors such as gender, environment and body size. From these, it has become clear that lens growth is not greatly affected by external influences. Although there are many similarities in the growth of lenses from different species, humans (and probably all primates) have distinctly different growth patterns, with prenatal and postnatal growth having different regulatory mechanisms. As a result, human lens properties are different from those of other species. Unfortunately, many of the published data are unreliable, presumably because of post-mortem changes, making it difficult to extrapolate in vitro observations to the in vivo situation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0816-4622
pubmed:author
pubmed:issnType
Print
pubmed:volume
91
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
226-39
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Growth of the lens: in vitro observations.
pubmed:affiliation
Institute for Eye Research and the Vision Cooperative Research Centre, University of New South Wales, Sydney, Australia. B.Augusteyn@ier.org.au
pubmed:publicationType
Journal Article, In Vitro, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural