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rdf:type |
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|
lifeskim:mentions |
|
|
pubmed:issue |
6
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|
pubmed:dateCreated |
1991-10-29
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pubmed:databankReference |
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pubmed:abstractText |
p107 is a cellular protein that forms specific complexes with adenovirus E1A and SV40 large T antigen (T). The genetics of the p107-T/E1A interaction as well as other features of this protein suggests that p107 shares functional properties with the tumor suppressor product, RB. A partial cDNA for human p107 has been cloned. Its sequences map to 20q11.2 and encode a 936 residue protein. Comparison analysis of the p107 protein sequence reveals a major region of RB homology extending over 564 residues. This region in RB is essential to its growth-controlling function. Sequences outside of these two regions are largely unique to each protein. The p107 and RB homology regions can independently bind to T and E1A. Thus, these two proteins display similarities of structure that may, at least in part, explain their known functional similarities and suggest a generic function for p107 in cell cycle regulation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0092-8674
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1155-64
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1833063-Adenovirus Early Proteins,
pubmed-meshheading:1833063-Amino Acid Sequence,
pubmed-meshheading:1833063-Antigens, Polyomavirus Transforming,
pubmed-meshheading:1833063-Base Sequence,
pubmed-meshheading:1833063-Chromosome Mapping,
pubmed-meshheading:1833063-Chromosomes, Human, Pair 20,
pubmed-meshheading:1833063-Cloning, Molecular,
pubmed-meshheading:1833063-Genes, Tumor Suppressor,
pubmed-meshheading:1833063-Humans,
pubmed-meshheading:1833063-Macromolecular Substances,
pubmed-meshheading:1833063-Molecular Sequence Data,
pubmed-meshheading:1833063-Nuclear Proteins,
pubmed-meshheading:1833063-Oncogene Proteins, Viral,
pubmed-meshheading:1833063-Protein Binding,
pubmed-meshheading:1833063-Proteins,
pubmed-meshheading:1833063-Retinoblastoma Protein,
pubmed-meshheading:1833063-Retinoblastoma-Like Protein p107,
pubmed-meshheading:1833063-Sequence Alignment
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pubmed:year |
1991
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|
pubmed:articleTitle |
Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein.
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pubmed:affiliation |
Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
