Linked Life Data

18329619

Source:http://linkedlifedata.com/resource/pubmed/id/18329619

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-3-21
pubmed:abstractText
The effect of treatment on relapses of Trypanosoma brucei (T. b.) brucei infections in mice in relation to passage of the parasites across the blood-brain barrier (BBB) as visualized by immunohistochemistry was studied. Three daily intraperitoneal injections of 20mg/kg suramin starting at 15 days post-infection (p.i.), when trypanosomes had begun to traverse the BBB, were curative, but not when starting at 21 days p.i. when parasite brain invasion was more pronounced. Relapses occurred in all mice after one or two daily injections of suramin starting at 15 days p.i., but they were delayed when treatment was supplemented with minocycline, which impedes penetration of T. b. brucei into the brain. This study supports the notion that suramin may be effective even when minor parasite neuroinvasion has appeared in African trypanosomiasis and it shows that minocyline can affect relapses of the disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0001-706X
pubmed:author
pubmed:issnType
Print
pubmed:volume
106
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
72-4
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Suramin and minocycline treatment of experimental African trypanososmiasis at an early stage of parasite brain invasion.
pubmed:affiliation
Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden. ndemamin@yahoo.co.uk <ndemamin@yahoo.co.uk>
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't