| pubmed-article:18329268 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18329268 | lifeskim:mentions | umls-concept:C0376358 | lld:lifeskim |
| pubmed-article:18329268 | lifeskim:mentions | umls-concept:C0031740 | lld:lifeskim |
| pubmed-article:18329268 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:18329268 | lifeskim:mentions | umls-concept:C0053917 | lld:lifeskim |
| pubmed-article:18329268 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:18329268 | lifeskim:mentions | umls-concept:C0301869 | lld:lifeskim |
| pubmed-article:18329268 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:18329268 | pubmed:dateCreated | 2008-4-3 | lld:pubmed |
| pubmed-article:18329268 | pubmed:abstractText | Sulfonated aluminum phthalocyanines (AlPcS) are potent photosensitizers for the photodynamic therapy (PDT) of cancer. In this study we evaluate the possibility to improve the efficacy of AlPcS-PDT for prostate cancer by targeting tetrasulfonated aluminum phthalocyanines (AlPcS(4)) to the gastrin-releasing peptide receptor (GRPR) through coupling to bombesin. A mono-carbohexyl derivative of AlPcS(4) is attached to 8-Aoc-bombesin(7-14)NH(2) via an amide bridge to yield a bombesin-AlPcS(4) conjugate linked by a C-14 spacer chain. The conjugate is characterized by mass spectroscopy and shown to bind to the GRPR with a relative binding affinity (RBA) of 2.3, taking bombesin (RBA=100) as unity. The in vitro photodynamic efficacy of the conjugate against PC-3 human prostate cancer cells is improved by a factor 2.5 over the non-conjugated mono-carbohexyl derivative of AlPcS(4). | lld:pubmed |
| pubmed-article:18329268 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18329268 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18329268 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18329268 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18329268 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18329268 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18329268 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18329268 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18329268 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18329268 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18329268 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:18329268 | pubmed:issn | 1464-3405 | lld:pubmed |
| pubmed-article:18329268 | pubmed:author | pubmed-author:KlarskovKlaus... | lld:pubmed |
| pubmed-article:18329268 | pubmed:author | pubmed-author:BénardFrançoi... | lld:pubmed |
| pubmed-article:18329268 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:18329268 | pubmed:author | pubmed-author:LangloisRéjea... | lld:pubmed |
| pubmed-article:18329268 | pubmed:author | pubmed-author:CauchonNicole... | lld:pubmed |
| pubmed-article:18329268 | pubmed:author | pubmed-author:TonePaulP | lld:pubmed |
| pubmed-article:18329268 | pubmed:author | pubmed-author:DubucCélénaC | lld:pubmed |
| pubmed-article:18329268 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18329268 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:18329268 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:18329268 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18329268 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18329268 | pubmed:pagination | 2424-7 | lld:pubmed |
| pubmed-article:18329268 | pubmed:meshHeading | pubmed-meshheading:18329268... | lld:pubmed |
| pubmed-article:18329268 | pubmed:meshHeading | pubmed-meshheading:18329268... | lld:pubmed |
| pubmed-article:18329268 | pubmed:meshHeading | pubmed-meshheading:18329268... | lld:pubmed |
| pubmed-article:18329268 | pubmed:meshHeading | pubmed-meshheading:18329268... | lld:pubmed |
| pubmed-article:18329268 | pubmed:meshHeading | pubmed-meshheading:18329268... | lld:pubmed |
| pubmed-article:18329268 | pubmed:meshHeading | pubmed-meshheading:18329268... | lld:pubmed |
| pubmed-article:18329268 | pubmed:meshHeading | pubmed-meshheading:18329268... | lld:pubmed |
| pubmed-article:18329268 | pubmed:meshHeading | pubmed-meshheading:18329268... | lld:pubmed |
| pubmed-article:18329268 | pubmed:meshHeading | pubmed-meshheading:18329268... | lld:pubmed |
| pubmed-article:18329268 | pubmed:meshHeading | pubmed-meshheading:18329268... | lld:pubmed |
| pubmed-article:18329268 | pubmed:meshHeading | pubmed-meshheading:18329268... | lld:pubmed |
| pubmed-article:18329268 | pubmed:meshHeading | pubmed-meshheading:18329268... | lld:pubmed |
| pubmed-article:18329268 | pubmed:meshHeading | pubmed-meshheading:18329268... | lld:pubmed |
| pubmed-article:18329268 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18329268 | pubmed:articleTitle | Targeting gastrin-releasing peptide receptors of prostate cancer cells for photodynamic therapy with a phthalocyanine-bombesin conjugate. | lld:pubmed |
| pubmed-article:18329268 | pubmed:affiliation | Department of Nuclear Medicine & Radiobiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, Que., Canada J1H 5N4. | lld:pubmed |
| pubmed-article:18329268 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18329268 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:18329268 | lld:chembl |
