Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2008-4-28
pubmed:abstractText
Osteoporosis is induced by a disorder of the bone turnover that generates an accelerated destruction process and leads to the rarefaction of the protein matrix. The RANK-L/RANK/OPG system is the main actor of the bone remodelling regulation. Juvenile osteoporoses may have primary or secondary aetiologies. The main causes include constitutional bone fragilities, and osteoporoses, which are secondary to chronic inflammatory diseases and sustained steroid treatment. Etiologic diagnosis relies on a clinical basis, and is often made too lately when complications occur. Osteodensitometry is a sensitive and noninvasive tool for measuring mineral bone density in children. The reliability of results is limited by the variations due to patients' age, gender, pubertal stage, and by the length of bone pieces. The optimal treatment of osteoporosis is preventive, and includes accurate nutritional diet, D vitamin-calcium supplementation and regular physical activity. Biphosphonates are used for treatment of symptomatic osteoporoses. Careful utilization is required in childhood because their late potential secondary effects are still unknown. New antiresorptive drugs and other that stimulate osteoformation are successfully used in adults. Their effects have not been studied in the paediatric population.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0929-693X
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
420-30
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
[Juvenile osteoporosis].
pubmed:affiliation
Service de réanimation, hôpital Robert-Debré, 48 boulevard Sérurier, Paris, France.
pubmed:publicationType
Journal Article, English Abstract, Review