| pubmed-article:18328786 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18328786 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:18328786 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:18328786 | pubmed:dateCreated | 2008-4-4 | lld:pubmed |
| pubmed-article:18328786 | pubmed:abstractText | The serine/threonine-specific protein kinase C-theta (PKC-theta) is a core component of the immunological synapse that was shown in vitro to play a central role in the activation of T cells after T cell receptor (TCR) and co-stimulatory molecule engagement. In recent years, a series of in vivo studies have shown that the situation is far more complex; specifically, PKC-theta signaling is differentially required for Th1, Th2, Th17 and CD8+ cytotoxic T-cell responses. These studies highlight the combination of signals that directly regulate T-cell differentiation and effector responses. In this review, we highlight recent in vivo studies investigating PKC-theta function and discuss this in the context of how the integration of extrinsic signals determines T cell fate and function. | lld:pubmed |
| pubmed-article:18328786 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18328786 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18328786 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18328786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18328786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18328786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18328786 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18328786 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:18328786 | pubmed:issn | 1471-4906 | lld:pubmed |
| pubmed-article:18328786 | pubmed:author | pubmed-author:KopfManfredM | lld:pubmed |
| pubmed-article:18328786 | pubmed:author | pubmed-author:MarslandBenja... | lld:pubmed |
| pubmed-article:18328786 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18328786 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:18328786 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18328786 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18328786 | pubmed:pagination | 179-85 | lld:pubmed |
| pubmed-article:18328786 | pubmed:meshHeading | pubmed-meshheading:18328786... | lld:pubmed |
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| pubmed-article:18328786 | pubmed:meshHeading | pubmed-meshheading:18328786... | lld:pubmed |
| pubmed-article:18328786 | pubmed:meshHeading | pubmed-meshheading:18328786... | lld:pubmed |
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| pubmed-article:18328786 | pubmed:meshHeading | pubmed-meshheading:18328786... | lld:pubmed |
| pubmed-article:18328786 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18328786 | pubmed:articleTitle | T-cell fate and function: PKC-theta and beyond. | lld:pubmed |
| pubmed-article:18328786 | pubmed:affiliation | Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology ETH, CH-8952 Zurich, Switzerland. marsland@env.ethz.ch | lld:pubmed |
| pubmed-article:18328786 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18328786 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:18328786 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18328786 | lld:pubmed |
