Linked Life Data

18328786

Source:http://linkedlifedata.com/resource/pubmed/id/18328786

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2008-4-4
pubmed:abstractText
The serine/threonine-specific protein kinase C-theta (PKC-theta) is a core component of the immunological synapse that was shown in vitro to play a central role in the activation of T cells after T cell receptor (TCR) and co-stimulatory molecule engagement. In recent years, a series of in vivo studies have shown that the situation is far more complex; specifically, PKC-theta signaling is differentially required for Th1, Th2, Th17 and CD8+ cytotoxic T-cell responses. These studies highlight the combination of signals that directly regulate T-cell differentiation and effector responses. In this review, we highlight recent in vivo studies investigating PKC-theta function and discuss this in the context of how the integration of extrinsic signals determines T cell fate and function.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1471-4906
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
179-85
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
T-cell fate and function: PKC-theta and beyond.
pubmed:affiliation
Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology ETH, CH-8952 Zurich, Switzerland. marsland@env.ethz.ch
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't