Source:http://linkedlifedata.com/resource/pubmed/id/18327256
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2008-3-27
|
| pubmed:abstractText |
Serum uric acid concentrations are correlated with gout and clinical entities such as cardiovascular disease and diabetes. In the genome-wide association study KORA (Kooperative Gesundheitsforschung in der Region Augsburg) F3 500K (n = 1,644), the most significant SNPs associated with uric acid concentrations mapped within introns 4 and 6 of SLC2A9, a gene encoding a putative hexose transporter (effects: -0.23 to -0.36 mg/dl per copy of the minor allele). We replicated these findings in three independent samples from Germany (KORA S4 and SHIP (Study of Health in Pomerania)) and Austria (SAPHIR; Salzburg Atherosclerosis Prevention Program in Subjects at High Individual Risk), with P values ranging from 1.2 x 10(-8) to 1.0 x 10(-32). Analysis of whole blood RNA expression profiles from a KORA F3 500K subgroup (n = 117) showed a significant association between the SLC2A9 isoform 2 and urate concentrations. The SLC2A9 genotypes also showed significant association with self-reported gout. The proportion of the variance of serum uric acid concentrations explained by genotypes was about 1.2% in men and 6% in women, and the percentage accounted for by expression levels was 3.5% in men and 15% in women.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
1546-1718
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| pubmed:author |
pubmed-author:CoassinStefanS,
pubmed-author:DöringAngelaA,
pubmed-author:FischerGuidoG,
pubmed-author:GiegerChristianC,
pubmed-author:GohlkeHenningH,
pubmed-author:HenkeKathleenK,
pubmed-author:IlligThomasT,
pubmed-author:KloppNormanN,
pubmed-author:KronenbergFlorianF,
pubmed-author:MehtaDivyaD,
pubmed-author:MeisingerChristaC,
pubmed-author:MeitingerThomasT,
pubmed-author:PaulweberBernhardB,
pubmed-author:PfeuferArneA,
pubmed-author:ProkischHolgerH,
pubmed-author:RosskopfDieterD,
pubmed-author:VölzkeHenryH,
pubmed-author:WichmannH-ErichHE
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| pubmed:issnType |
Electronic
|
| pubmed:volume |
40
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
430-6
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| pubmed:meshHeading |
pubmed-meshheading:18327256-Adult,
pubmed-meshheading:18327256-Aged,
pubmed-meshheading:18327256-Aged, 80 and over,
pubmed-meshheading:18327256-Austria,
pubmed-meshheading:18327256-Biological Markers,
pubmed-meshheading:18327256-Case-Control Studies,
pubmed-meshheading:18327256-Computational Biology,
pubmed-meshheading:18327256-Female,
pubmed-meshheading:18327256-Genome, Human,
pubmed-meshheading:18327256-Genotype,
pubmed-meshheading:18327256-Germany,
pubmed-meshheading:18327256-Glucose Transport Proteins, Facilitative,
pubmed-meshheading:18327256-Gout,
pubmed-meshheading:18327256-Humans,
pubmed-meshheading:18327256-Male,
pubmed-meshheading:18327256-Middle Aged,
pubmed-meshheading:18327256-Polymorphism, Single Nucleotide,
pubmed-meshheading:18327256-Sex Distribution,
pubmed-meshheading:18327256-Spectrometry, Mass, Matrix-Assisted Laser...,
pubmed-meshheading:18327256-Uric Acid
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
SLC2A9 influences uric acid concentrations with pronounced sex-specific effects.
|
| pubmed:affiliation |
Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
|