Linked Life Data

18326317

Source:http://linkedlifedata.com/resource/pubmed/id/18326317

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-3-10
pubmed:abstractText
Iron is essential for all living organisms. Iron is taken up from the foods by enterocytes of the duodenum and proximal jejunum, and then released into the plasma and transported to whole body by binding to transferrin. Transferrin-bound iron is utilized mainly for erythropoiesis at the bone marrow, in which iron is essential for the formation of heme. Recently, a new anti-microbial peptide, named hepcidin, was identified, and hepcidin is found to function as the regulator of body iron metabolism by inhibiting iron uptake at enterocyte and iron release from reticuloendothelial macrophages. Hepcidin is produced by hepatocytes, and the expression is modulated by inflammation so that hepcidin is thought to be involved in the pathophysiology of anemia of chronic disease. Research in the iron metabolism field has been developing rapidly these years, and the new innovational therapies for the disease caused by the dysregulation of iron metabolism are expected.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0047-1852
pubmed:author
pubmed:issnType
Print
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
469-74
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
[Iron metabolism and anemia].
pubmed:affiliation
Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical College.
pubmed:publicationType
Journal Article, English Abstract, Review