| pubmed-article:1832598 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1832598 | lifeskim:mentions | umls-concept:C0019693 | lld:lifeskim |
| pubmed-article:1832598 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:1832598 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:1832598 | lifeskim:mentions | umls-concept:C0242629 | lld:lifeskim |
| pubmed-article:1832598 | lifeskim:mentions | umls-concept:C0079720 | lld:lifeskim |
| pubmed-article:1832598 | lifeskim:mentions | umls-concept:C0085115 | lld:lifeskim |
| pubmed-article:1832598 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:1832598 | lifeskim:mentions | umls-concept:C0108779 | lld:lifeskim |
| pubmed-article:1832598 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:1832598 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:1832598 | lifeskim:mentions | umls-concept:C1515021 | lld:lifeskim |
| pubmed-article:1832598 | lifeskim:mentions | umls-concept:C1304884 | lld:lifeskim |
| pubmed-article:1832598 | lifeskim:mentions | umls-concept:C0686907 | lld:lifeskim |
| pubmed-article:1832598 | lifeskim:mentions | umls-concept:C0333668 | lld:lifeskim |
| pubmed-article:1832598 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1832598 | pubmed:dateCreated | 1991-10-24 | lld:pubmed |
| pubmed-article:1832598 | pubmed:abstractText | In order to highlight the underlying mechanism(s) of the CD8 lymphocyte expansion in the HIV infection, two distinct CD8 subsets were analysed: T CD8bright+ CD3+ with MHC-restricted activity, and non-T CD8dim+ CD3-, which performs natural killer (NK) activity. It consists of a cross-sectional study including 168 HIV-infected patients (74 CDC stage II, 48 CDC stage III and 46 CDC stage IV) compared among them and to 60 healthy individuals. We observed an expansion of CD8+ CD3+ cells which masks a depletion of CD8+ CD3-. The comparative study showed that the expansion of the CD8+ CD3+ is relatively higher than that of total CD8+ lymphocytes and that the depletion of the CD8+ CD3- subset is severe, begins early and remains constant through the HIV progression. The comparison of CD4/CD8 and CD4/CD8+ CD3+ ratios showed that the latter could possibly be a better indicator in the HIV infection. The mechanism of inverted CD4/CD8 ratio in healthy individuals was also clarified. The CD8+ CD3+, CD8+ CD3- and CD4/CD8+ CD3+ parameters would be more specific markers than total CD8 and CD4/CD8 ratio especially in therapy trials. | lld:pubmed |
| pubmed-article:1832598 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1832598 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1832598 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1832598 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1832598 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1832598 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1832598 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:1832598 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:1832598 | pubmed:author | pubmed-author:RougerPP | lld:pubmed |
| pubmed-article:1832598 | pubmed:author | pubmed-author:DoinelCC | lld:pubmed |
| pubmed-article:1832598 | pubmed:author | pubmed-author:MansourII | lld:pubmed |
| pubmed-article:1832598 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1832598 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:1832598 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1832598 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1832598 | pubmed:pagination | 481-4 | lld:pubmed |
| pubmed-article:1832598 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:1832598 | pubmed:meshHeading | pubmed-meshheading:1832598-... | lld:pubmed |
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| pubmed-article:1832598 | pubmed:meshHeading | pubmed-meshheading:1832598-... | lld:pubmed |
| pubmed-article:1832598 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1832598 | pubmed:articleTitle | Dichotomy of two CD8+ lymphocyte subsets in HIV infection. Depletion of CD8+ CD3- and expansion of CD8+ CD3+ subsets: consequence on the CD4/CD8 ratio. | lld:pubmed |
| pubmed-article:1832598 | pubmed:affiliation | Institut National de Transfusion Sanguine, Paris, France. | lld:pubmed |
| pubmed-article:1832598 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1832598 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1832598 | lld:pubmed |
