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rdf:type |
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lifeskim:mentions |
umls-concept:C0019693,
umls-concept:C0079720,
umls-concept:C0085115,
umls-concept:C0085358,
umls-concept:C0108779,
umls-concept:C0242629,
umls-concept:C0333668,
umls-concept:C0686907,
umls-concept:C1304884,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1515021,
umls-concept:C1706438,
umls-concept:C2698600
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pubmed:issue |
3
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pubmed:dateCreated |
1991-10-24
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pubmed:abstractText |
In order to highlight the underlying mechanism(s) of the CD8 lymphocyte expansion in the HIV infection, two distinct CD8 subsets were analysed: T CD8bright+ CD3+ with MHC-restricted activity, and non-T CD8dim+ CD3-, which performs natural killer (NK) activity. It consists of a cross-sectional study including 168 HIV-infected patients (74 CDC stage II, 48 CDC stage III and 46 CDC stage IV) compared among them and to 60 healthy individuals. We observed an expansion of CD8+ CD3+ cells which masks a depletion of CD8+ CD3-. The comparative study showed that the expansion of the CD8+ CD3+ is relatively higher than that of total CD8+ lymphocytes and that the depletion of the CD8+ CD3- subset is severe, begins early and remains constant through the HIV progression. The comparison of CD4/CD8 and CD4/CD8+ CD3+ ratios showed that the latter could possibly be a better indicator in the HIV infection. The mechanism of inverted CD4/CD8 ratio in healthy individuals was also clarified. The CD8+ CD3+, CD8+ CD3- and CD4/CD8+ CD3+ parameters would be more specific markers than total CD8 and CD4/CD8 ratio especially in therapy trials.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1832598-2150319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1832598-2199174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1832598-2455615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1832598-2966211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1832598-2988392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1832598-3006568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1832598-3156193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1832598-3262463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1832598-3510102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1832598-6213860,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1832598-6226586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1832598-6229182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1832598-6262407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1832598-6328660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1832598-6408172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1832598-6450326
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
85
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
481-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1832598-Adult,
pubmed-meshheading:1832598-Antigens, CD3,
pubmed-meshheading:1832598-Antigens, CD4,
pubmed-meshheading:1832598-Antigens, CD8,
pubmed-meshheading:1832598-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:1832598-Flow Cytometry,
pubmed-meshheading:1832598-HIV Infections,
pubmed-meshheading:1832598-Humans,
pubmed-meshheading:1832598-Leukocyte Count,
pubmed-meshheading:1832598-Lymphocyte Subsets,
pubmed-meshheading:1832598-Middle Aged,
pubmed-meshheading:1832598-Receptors, Antigen, T-Cell
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pubmed:year |
1991
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pubmed:articleTitle |
Dichotomy of two CD8+ lymphocyte subsets in HIV infection. Depletion of CD8+ CD3- and expansion of CD8+ CD3+ subsets: consequence on the CD4/CD8 ratio.
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pubmed:affiliation |
Institut National de Transfusion Sanguine, Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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