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rdf:type |
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|
lifeskim:mentions |
|
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pubmed:issue |
7
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pubmed:dateCreated |
2008-4-3
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pubmed:abstractText |
A new class of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-chalcone conjugates have been prepared by employing a solid-phase synthetic protocol. In this strategy an intramolecular aza-Wittig reductive cyclization approach has been utilized. Interestingly, some of these molecules have shown enhanced DNA-binding affinity and promising anticancer activity on a large number of human cancer cell lines.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
|
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pubmed:issn |
1464-3405
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
18
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2434-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:18325766-Antineoplastic Agents,
pubmed-meshheading:18325766-Benzodiazepines,
pubmed-meshheading:18325766-Binding Sites,
pubmed-meshheading:18325766-Cell Line, Tumor,
pubmed-meshheading:18325766-Chalcone,
pubmed-meshheading:18325766-DNA,
pubmed-meshheading:18325766-Drug Screening Assays, Antitumor,
pubmed-meshheading:18325766-Humans,
pubmed-meshheading:18325766-Models, Chemical,
pubmed-meshheading:18325766-Pyrroles,
pubmed-meshheading:18325766-Structure-Activity Relationship
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pubmed:year |
2008
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pubmed:articleTitle |
Solid-phase synthesis of new pyrrolobenzodiazepine-chalcone conjugates: DNA-binding affinity and anticancer activity.
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pubmed:affiliation |
Chemical Biology Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad, Andra Pradesh 500 007, India. ahmedkamal@iict.res.in
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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