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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2008-4-10
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pubmed:abstractText |
We envisioned that label-free control of the transport of cells in two dimensions through receptor-ligand interactions would enable simple separation systems that are easy to implement yet retain the specificity of receptor-ligand interactions. Here we demonstrate nanomechanical control of cell transport in two dimensions via transient receptor-ligand adhesive bonds by patterning of receptors that direct cell rolling through an edge effect. HL-60 cells rolling on P-selectin receptor patterns were deflected at angles of 5-10 degrees with respect to their direction of travel. Absence of this effect in the case of rigid microsphere models of cell rolling suggests that this two-dimensional motion depends on nanomechanical properties of the rolling cell. This work suggests the feasibility of simple continuous-flow microfluidic cell separation systems that minimize processing steps and yet retain the specificity of receptor-ligand interactions.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18321075-10609516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18321075-10791984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18321075-11071658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18321075-11255159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18321075-12540203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18321075-12736689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18321075-15143275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18321075-15279555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18321075-15353601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18321075-15616742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18321075-15653718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18321075-15653735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18321075-15879471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18321075-16100282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18321075-17267403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18321075-17949112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18321075-17973400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18321075-18030382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18321075-288488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18321075-347575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18321075-7513527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18321075-7534768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18321075-7535385,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18321075-7542213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18321075-8182345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18321075-8541529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18321075-9024700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18321075-9281593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18321075-9885254
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1530-6984
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1153-8
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pubmed:dateRevised |
2011-4-28
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pubmed:meshHeading |
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pubmed:year |
2008
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pubmed:articleTitle |
Nanomechanical control of cell rolling in two dimensions through surface patterning of receptors.
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pubmed:affiliation |
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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