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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2008-5-9
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pubmed:abstractText |
Natural killer (NK) cells have been originally defined by their "naturally occurring" effector function. However, only a fraction of human NK cells is reactive toward a panel of prototypical tumor cell targets in vitro, both for the production of interferon-gamma (IFN-gamma) and for their cytotoxic response. In patients with IL12RB1 mutations that lead to a complete IL-12Rbeta1 deficiency, the size of this naturally reactive NK cell subset is diminished, in particular for the IFN-gamma production. Similar data were obtained from a patient with a complete deficit in IL-12p40. In addition, the size of the subset of effector memory T cells expressing CD56 was severely decreased in IL-12Rbeta1- and IL-12p40-deficient patients. Human NK cells thus require in vivo priming with IL-12/23 to acquire their full spectrum of functional reactivity, while T cells are dependent upon IL-12/23 signals for the differentiation and/or the maintenance of CD56(+) effector memory T cells. The susceptibility of IL-12/23 axis-deficient patients to Mycobacterium and Salmonella infections in combination with the absence of mycobacteriosis or salmonellosis in the rare cases of human NK cell deficiencies point to a role for CD56(+) T cells in the control of these infections in humans.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1528-0020
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pubmed:author |
pubmed-author:AbelLaurentL,
pubmed-author:Al JumaahSulimanS,
pubmed-author:Al-HajjarSamiS,
pubmed-author:BergerClaireC,
pubmed-author:BrossayLaurentL,
pubmed-author:CamciogluYildizY,
pubmed-author:CasanovaJean-LaurentJL,
pubmed-author:CognetCélineC,
pubmed-author:FeinbergJacquelineJ,
pubmed-author:FieschiClaireC,
pubmed-author:Filipe-SantosOrchidéeO,
pubmed-author:GuiaSophieS,
pubmed-author:JouanguyEmmanuelleE,
pubmed-author:LevyJacobJ,
pubmed-author:StephanJean-LouisJL,
pubmed-author:TessmerMarlowe SMS,
pubmed-author:VivierEricE,
pubmed-author:de BeaucoudreyLudovicL
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
111
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5008-16
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pubmed:meshHeading |
pubmed-meshheading:18319400-Adolescent,
pubmed-meshheading:18319400-Adult,
pubmed-meshheading:18319400-Antigens, CD56,
pubmed-meshheading:18319400-Child,
pubmed-meshheading:18319400-Child, Preschool,
pubmed-meshheading:18319400-Disease Susceptibility,
pubmed-meshheading:18319400-Female,
pubmed-meshheading:18319400-Humans,
pubmed-meshheading:18319400-Immunologic Memory,
pubmed-meshheading:18319400-Interleukin-12,
pubmed-meshheading:18319400-Interleukin-12 Subunit p40,
pubmed-meshheading:18319400-Interleukin-23,
pubmed-meshheading:18319400-Killer Cells, Natural,
pubmed-meshheading:18319400-Male,
pubmed-meshheading:18319400-Mutation,
pubmed-meshheading:18319400-Mycobacterium Infections,
pubmed-meshheading:18319400-Receptors, Interleukin-12,
pubmed-meshheading:18319400-Salmonella Infections,
pubmed-meshheading:18319400-T-Lymphocytes
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pubmed:year |
2008
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pubmed:articleTitle |
A role for interleukin-12/23 in the maturation of human natural killer and CD56+ T cells in vivo.
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pubmed:affiliation |
Centre d'Immunologie de Marseille-Luminy, Université de la Méditerranée, Marseille, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
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