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rdf:type |
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lifeskim:mentions |
umls-concept:C0002199,
umls-concept:C0005767,
umls-concept:C0011306,
umls-concept:C0086418,
umls-concept:C0221099,
umls-concept:C0681850,
umls-concept:C0700624,
umls-concept:C0963057,
umls-concept:C1516240,
umls-concept:C1550501,
umls-concept:C1706203,
umls-concept:C2349001,
umls-concept:C2697811
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pubmed:issue |
5
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pubmed:dateCreated |
2008-4-18
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pubmed:abstractText |
High-affinity IgE receptor (Fc epsilon RI) expression on blood dendritic cells reportedly correlates with serum IgE levels. Our studies demonstrate that plasmacytoid dendritic cells (pDCs) secrete pro-inflammatory cytokines (IL-6, TNF-alpha) following Fc epsilon RI stimulation - a mode of activation that simultaneously reduces expression of Toll-like receptor 9 (TLR9). Whether or not TLR9 and/or Fc epsilon RI levels and their function on dendritic cells relate to allergic status is unknown.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18318750-10364556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18318750-11748283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18318750-11893858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18318750-12532094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18318750-14657872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18318750-14976261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18318750-15549123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18318750-15800576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18318750-15998792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18318750-16237063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18318750-16418803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18318750-16499644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18318750-16604075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18318750-16735691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18318750-17021320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18318750-17052915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18318750-17116765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18318750-17417641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18318750-17479100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18318750-17508961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18318750-17873860,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18318750-7519213
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1365-2222
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
781-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18318750-Adult,
pubmed-meshheading:18318750-Asthma,
pubmed-meshheading:18318750-CpG Islands,
pubmed-meshheading:18318750-Dendritic Cells,
pubmed-meshheading:18318750-Female,
pubmed-meshheading:18318750-Food Hypersensitivity,
pubmed-meshheading:18318750-Humans,
pubmed-meshheading:18318750-Hypersensitivity, Immediate,
pubmed-meshheading:18318750-Interferon-alpha,
pubmed-meshheading:18318750-Male,
pubmed-meshheading:18318750-Middle Aged,
pubmed-meshheading:18318750-Receptors, IgE,
pubmed-meshheading:18318750-Rhinitis, Allergic, Perennial,
pubmed-meshheading:18318750-Rhinitis, Allergic, Seasonal,
pubmed-meshheading:18318750-Toll-Like Receptor 9
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pubmed:year |
2008
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pubmed:articleTitle |
Human blood dendritic cells from allergic subjects have impaired capacity to produce interferon-alpha via Toll-like receptor 9.
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pubmed:affiliation |
Department of Medicine, Johns Hopkins Asthma and Allergy Center, Division of Allergy and Clinical Immunology, Johns Hopkins University, Baltimore, MD 21224, USA. Jodytversky@yahoo.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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