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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1991-10-3
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pubmed:abstractText |
The anti-allergic and anti-asthmatic activities of three potassium (K+) channel openers, cromakalim, pinacidil, and nicorandil, were investigated. 1) Forty-eight-hour homologous passive cutaneous anaphylaxis (PCA) in mice was not affected by cromakalim, pinacidil, or nicorandil. Ketotifen significantly inhibited the reaction. 2) Antigen-induced histamine release from sensitized guinea pig lung tissue was not affected by cromakalim, pinacidil or nicorandil (except for 10(-4) M nicorandil). Salbutamol inhibited the release of histamine. 3) Histamine, serotonin and LTC4-induced vasculitis in rat back skin was not affected by any of these three K+ channel openers. 4) Antigen-induced constriction of isolated sensitized guinea pig tracheal muscle was relaxed by each of the K+ channel openers. 5) Constrictions of isolated guinea pig tracheal muscle caused by high potassium, histamine, LTC4, or U-46619 were clearly relaxed by each of the three K+ channel openers. 6) Increases of airway resistance caused by histamine, LTD4, or U-46619 in guinea pigs in vivo were inhibited by administration of each of the three K+ channel openers. 7) Experimental asthma caused by the IgE antibody and antigen system in guinea pigs was inhibited by each of the three K+ channel openers.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Benzopyrans,
http://linkedlifedata.com/resource/pubmed/chemical/Bronchodilator Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Cromakalim,
http://linkedlifedata.com/resource/pubmed/chemical/Guanidines,
http://linkedlifedata.com/resource/pubmed/chemical/Niacinamide,
http://linkedlifedata.com/resource/pubmed/chemical/Nicorandil,
http://linkedlifedata.com/resource/pubmed/chemical/Pinacidil,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrroles
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0021-5198
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
13-21
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1831870-Airway Resistance,
pubmed-meshheading:1831870-Animals,
pubmed-meshheading:1831870-Asthma,
pubmed-meshheading:1831870-Benzopyrans,
pubmed-meshheading:1831870-Bronchodilator Agents,
pubmed-meshheading:1831870-Cromakalim,
pubmed-meshheading:1831870-Guanidines,
pubmed-meshheading:1831870-Guinea Pigs,
pubmed-meshheading:1831870-Mice,
pubmed-meshheading:1831870-Mice, Inbred Strains,
pubmed-meshheading:1831870-Niacinamide,
pubmed-meshheading:1831870-Nicorandil,
pubmed-meshheading:1831870-Passive Cutaneous Anaphylaxis,
pubmed-meshheading:1831870-Pinacidil,
pubmed-meshheading:1831870-Potassium Channels,
pubmed-meshheading:1831870-Pyrroles,
pubmed-meshheading:1831870-Rats,
pubmed-meshheading:1831870-Trachea,
pubmed-meshheading:1831870-Vasculitis
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pubmed:year |
1991
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pubmed:articleTitle |
Effect of three novel K+ channel openers, cromakalim, pinacidil and nicorandil on allergic reaction and experimental asthma.
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pubmed:affiliation |
Department of Pharmacology, Gifu Pharmaceutical University, Japan.
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pubmed:publicationType |
Journal Article,
In Vitro
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