Linked Life Data

18317227

Source:http://linkedlifedata.com/resource/pubmed/id/18317227

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-3-21
pubmed:abstractText
Reproducible subclassification of ovarian carcinomas is biologically and increasingly therapeutically important. The traditional morphologic approach that ignores genotype and immunophenotype is subjective and therefore suboptimal. This review covers the prevalence, morphology, immunophenotype and, in some cases, genotype of each major ovarian cancer subtype. Serous carcinomas, frequently WT1 positive, are morphologically diverse and mimic other tumors. Most transitional cell carcinomas are closely related to them. Mucinous carcinomas are uncommon and should only be diagnosed after extraovarian primaries are excluded; true ovarian mucinous carcinomas are usually low stage. Intestinal and mullerian mucinous (seromucinous) tumors are histogenetically and clinically distinct. Ovarian endometrioid carcinomas almost always resemble endometrioid carcinomas of endometrium, express estrogen receptors (ER) but not WT1, and are frequently low grade and low stage. Ovarian clear cell carcinomas, negative for ER and WT1 and lacking p53 overexpression, have a limited morphologic repertoire and are frequently low stage at presentation. Clinical biology, immunohistochemistry, and genotype can be used to enhance diagnostic objectivity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1538-7151
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
161-74
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Histologic subtypes of ovarian carcinoma: an overview.
pubmed:affiliation
Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. soslowr@mskcc.org
pubmed:publicationType
Journal Article, Review