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rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0034115,
umls-concept:C0038952,
umls-concept:C0206430,
umls-concept:C0449432,
umls-concept:C0664943,
umls-concept:C1179435,
umls-concept:C1417898,
umls-concept:C1524073,
umls-concept:C1548799,
umls-concept:C1705248,
umls-concept:C1864009,
umls-concept:C2349975
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|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2008-3-4
|
|
pubmed:abstractText |
Tpn is a member of the MHC class I loading complex and functions to bridge the TAP peptide transporter to MHC class I molecules. Metastatic human carcinomas often express low levels of the antigen-processing components Tapasin and TAP and display few functional surface MHC class I molecules. As a result, carcinomas are unrecognizable by effector CTLs. The aim of this study is to examine if Tapasin (Tpn) plays a critical role in the escape of tumors from immunologic recognition.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
1078-0432
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:day |
1
|
|
pubmed:volume |
14
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1494-501
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|
pubmed:meshHeading |
pubmed-meshheading:18316574-ATP-Binding Cassette Transporters,
pubmed-meshheading:18316574-Adenoviridae,
pubmed-meshheading:18316574-Animals,
pubmed-meshheading:18316574-Antigen Presentation,
pubmed-meshheading:18316574-CD4-Positive T-Lymphocytes,
pubmed-meshheading:18316574-CD8-Positive T-Lymphocytes,
pubmed-meshheading:18316574-Cell Line, Tumor,
pubmed-meshheading:18316574-Cross-Priming,
pubmed-meshheading:18316574-Dendritic Cells,
pubmed-meshheading:18316574-Disease-Free Survival,
pubmed-meshheading:18316574-Histocompatibility Antigens Class I,
pubmed-meshheading:18316574-Humans,
pubmed-meshheading:18316574-Lung Neoplasms,
pubmed-meshheading:18316574-Lymphocytes, Tumor-Infiltrating,
pubmed-meshheading:18316574-Membrane Transport Proteins,
pubmed-meshheading:18316574-Mice,
pubmed-meshheading:18316574-Mice, Inbred C57BL,
pubmed-meshheading:18316574-Spleen,
pubmed-meshheading:18316574-Survival Rate,
pubmed-meshheading:18316574-T-Lymphocytes, Cytotoxic
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|
pubmed:year |
2008
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|
pubmed:articleTitle |
Combining the antigen processing components TAP and Tapasin elicits enhanced tumor-free survival.
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|
pubmed:affiliation |
Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
