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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2008-3-4
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pubmed:abstractText |
Basal-like breast cancer is associated with high grade, poor prognosis, and younger patient age. Clinically, a triple-negative phenotype definition [estrogen receptor, progesterone receptor, and human epidermal growth factor receptor (HER)-2, all negative] is commonly used to identify such cases. EGFR and cytokeratin 5/6 are readily available positive markers of basal-like breast cancer applicable to standard pathology specimens. This study directly compares the prognostic significance between three- and five-biomarker surrogate panels to define intrinsic breast cancer subtypes, using a large clinically annotated series of breast tumors.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Keratin-5,
http://linkedlifedata.com/resource/pubmed/chemical/Keratin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, erbB-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Estrogen,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Progesterone,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1368-76
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18316557-Adult,
pubmed-meshheading:18316557-Aged,
pubmed-meshheading:18316557-Breast Neoplasms,
pubmed-meshheading:18316557-Cohort Studies,
pubmed-meshheading:18316557-Female,
pubmed-meshheading:18316557-Follow-Up Studies,
pubmed-meshheading:18316557-Humans,
pubmed-meshheading:18316557-Immunoenzyme Techniques,
pubmed-meshheading:18316557-In Situ Hybridization, Fluorescence,
pubmed-meshheading:18316557-Keratin-5,
pubmed-meshheading:18316557-Keratin-6,
pubmed-meshheading:18316557-Middle Aged,
pubmed-meshheading:18316557-Neoplasm Invasiveness,
pubmed-meshheading:18316557-Prognosis,
pubmed-meshheading:18316557-Receptor, Epidermal Growth Factor,
pubmed-meshheading:18316557-Receptor, erbB-2,
pubmed-meshheading:18316557-Receptors, Estrogen,
pubmed-meshheading:18316557-Receptors, Progesterone,
pubmed-meshheading:18316557-Tumor Markers, Biological
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pubmed:year |
2008
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pubmed:articleTitle |
Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype.
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pubmed:affiliation |
Genetic Pathology Evaluation Centre, Vancouver Coastal Health Research Institute, British Columbia Cancer Agency, and University of British Columbia, Vancouver, British Columbia, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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