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rdf:type |
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lifeskim:mentions |
umls-concept:C0024204,
umls-concept:C0034802,
umls-concept:C0036525,
umls-concept:C0040649,
umls-concept:C0040661,
umls-concept:C0070948,
umls-concept:C0086982,
umls-concept:C0278996,
umls-concept:C0525010,
umls-concept:C0936012,
umls-concept:C1441616,
umls-concept:C1522484,
umls-concept:C1705162,
umls-concept:C1710082
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pubmed:issue |
5
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pubmed:dateCreated |
2008-3-4
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pubmed:abstractText |
To determine the effect of tyrosine-phosphorylated signal transducer and activator of transcription 3 (pSTAT3) immunoexpression on survival in two independent cohorts of patients with squamous cell carcinoma of the head and neck (SCCHN) and to evaluate pSTAT3, transforming growth factor-alpha (TGF-alpha), epidermal growth factor receptor (EGFR), and gastrin-releasing peptide receptor (GRPR) expression in matched tumor and lymph node metastases in one of these cohorts. EXPERIMENTAL TECHNIQUE: Immunostaining for pSTAT3, TGF-alpha, EGFR, and GRPR was done in two SCCHN cohorts (cohort 1, 61 tumors; cohort 2, 69 paired primary tumors and lymph node metastases). Semiquantitative scores derived from the product of staining intensity (scale 0-3) score and percentage of positive tumor cells were correlated with clinical outcome.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1303-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18316548-Adult,
pubmed-meshheading:18316548-Aged,
pubmed-meshheading:18316548-Aged, 80 and over,
pubmed-meshheading:18316548-Carcinoma, Squamous Cell,
pubmed-meshheading:18316548-Cohort Studies,
pubmed-meshheading:18316548-Female,
pubmed-meshheading:18316548-Head and Neck Neoplasms,
pubmed-meshheading:18316548-Humans,
pubmed-meshheading:18316548-Immunoenzyme Techniques,
pubmed-meshheading:18316548-Lymph Nodes,
pubmed-meshheading:18316548-Lymphatic Metastasis,
pubmed-meshheading:18316548-Male,
pubmed-meshheading:18316548-Middle Aged,
pubmed-meshheading:18316548-Phosphotyrosine,
pubmed-meshheading:18316548-Receptor, Epidermal Growth Factor,
pubmed-meshheading:18316548-Receptors, Bombesin,
pubmed-meshheading:18316548-STAT3 Transcription Factor,
pubmed-meshheading:18316548-Signal Transduction,
pubmed-meshheading:18316548-Transcriptional Activation,
pubmed-meshheading:18316548-Transforming Growth Factor alpha
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pubmed:year |
2008
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pubmed:articleTitle |
Immunohistochemical analysis of phosphotyrosine signal transducer and activator of transcription 3 and epidermal growth factor receptor autocrine signaling pathways in head and neck cancers and metastatic lymph nodes.
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pubmed:affiliation |
Department of Otolaryngology, University of Pittsburgh and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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