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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2008-3-18
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pubmed:abstractText |
Protein kinase A signaling has long been known to play an important role in cardiac function. Dysregulation of the protein kinase A system, caused by mutation of the protein kinase A regulatory subunit gene PRKAR1A, causes the inherited tumor syndrome Carney complex, which includes cardiac myxomas as one of its cardinal features. Mouse models of this genetic defect have been unsatisfactory because homozygote null animals die early in development and heterozygotes do not exhibit a cardiac phenotype.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
18
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pubmed:volume |
117
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1414-22
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pubmed:meshHeading |
pubmed-meshheading:18316483-Animals,
pubmed-meshheading:18316483-Apoptosis,
pubmed-meshheading:18316483-Cell Division,
pubmed-meshheading:18316483-Cyclic AMP-Dependent Protein Kinase RIalpha Subunit,
pubmed-meshheading:18316483-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:18316483-Down-Regulation,
pubmed-meshheading:18316483-Fetal Death,
pubmed-meshheading:18316483-Fetal Heart,
pubmed-meshheading:18316483-Genes, Lethal,
pubmed-meshheading:18316483-Heart Neoplasms,
pubmed-meshheading:18316483-Integrases,
pubmed-meshheading:18316483-Mice,
pubmed-meshheading:18316483-Mice, Knockout,
pubmed-meshheading:18316483-Models, Animal,
pubmed-meshheading:18316483-Myocytes, Cardiac,
pubmed-meshheading:18316483-Myxoma,
pubmed-meshheading:18316483-Neoplastic Syndromes, Hereditary,
pubmed-meshheading:18316483-Organ Specificity,
pubmed-meshheading:18316483-Transcription Factors
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pubmed:year |
2008
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pubmed:articleTitle |
Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis.
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pubmed:affiliation |
Department of Molecular Virology, Immunology, and Molecular Genetics, Ohio State University, Columbus, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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