18316420

Source:http://linkedlifedata.com/resource/pubmed/id/18316420

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0004083, umls-concept:C0028043, umls-concept:C0058698, umls-concept:C0086190, umls-concept:C0205251, umls-concept:C0470187, umls-concept:C2348205
pubmed:issue	4
pubmed:dateCreated	2008-4-2
pubmed:abstractText	All drugs of abuse induce a phasic dopamine release within the striatum that does not undergo habituation. Prolonged substance consumption impairs the natural function of the mesolimbic dopamine system, as shown by a decrease in the availability of striatal dopamine 2 (D(2)) receptors in patients suffering from cocaine, heroin, amphetamine, and alcohol dependence. However, it is unclear whether similar changes can also be observed in heavy-smoking nicotine-dependent smokers.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0370512
pubmed:citationSubset	AIM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Benzamides, http://linkedlifedata.com/resource/pubmed/chemical/Carbon Radioisotopes, http://linkedlifedata.com/resource/pubmed/chemical/Fluorine Radioisotopes, http://linkedlifedata.com/resource/pubmed/chemical/Pyrrolidines, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D2, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D3
pubmed:status	MEDLINE
pubmed:month	Apr
pubmed:issn	0002-953X
pubmed:author	pubmed-author:BartensteinPeterP, pubmed-author:BuchholzHans-GeorgHG, pubmed-author:DeckersHannaH, pubmed-author:DielentheisThomasT, pubmed-author:EberhardtAlexandraA, pubmed-author:FehrChristophC, pubmed-author:GründerGerhardG, pubmed-author:HohmannNinaN, pubmed-author:KlägerMarieM, pubmed-author:LandvogtChristianC, pubmed-author:RöschFrankF, pubmed-author:ScheurichArminA, pubmed-author:SchmidtLutz GLG, pubmed-author:SchreckenbergerMathiasM, pubmed-author:SmolkaMichael NMN, pubmed-author:YakushevIgorI
pubmed:issnType	Print
pubmed:volume	165
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	507-14
pubmed:meshHeading	pubmed-meshheading:18316420-Adult, pubmed-meshheading:18316420-Basal Ganglia, pubmed-meshheading:18316420-Behavior, Addictive, pubmed-meshheading:18316420-Benzamides, pubmed-meshheading:18316420-Carbon Radioisotopes, pubmed-meshheading:18316420-Fluorine Radioisotopes, pubmed-meshheading:18316420-Functional Laterality, pubmed-meshheading:18316420-Gyrus Cinguli, pubmed-meshheading:18316420-Humans, pubmed-meshheading:18316420-Male, pubmed-meshheading:18316420-Positron-Emission Tomography, pubmed-meshheading:18316420-Pyrrolidines, pubmed-meshheading:18316420-Receptors, Dopamine D2, pubmed-meshheading:18316420-Receptors, Dopamine D3, pubmed-meshheading:18316420-Smoking, pubmed-meshheading:18316420-Substance Withdrawal Syndrome, pubmed-meshheading:18316420-Substance-Related Disorders, pubmed-meshheading:18316420-Temporal Lobe, pubmed-meshheading:18316420-Tobacco Use Disorder
pubmed:year	2008
pubmed:articleTitle	Association of low striatal dopamine d2 receptor availability with nicotine dependence similar to that seen with other drugs of abuse.
pubmed:affiliation	Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, 55131 Mainz, Germany. fehrc@uni-mainz.de
pubmed:publicationType	Journal Article, Comparative Study, Research Support, Non-U.S. Gov't