18316188

Source:http://linkedlifedata.com/resource/pubmed/id/18316188

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0023175, umls-concept:C0243192, umls-concept:C0597357, umls-concept:C2697525
pubmed:issue	6
pubmed:dateCreated	2008-3-17
pubmed:abstractText	A series of small molecule orally bioavailable ghrelin receptor agonists have been identified through systematic optimisation of a high throughput screening hit.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Indoles, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Serotonin, 5-HT1B, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Ghrelin, http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides
pubmed:status	MEDLINE
pubmed:month	Mar
pubmed:issn	1464-3405
pubmed:author	pubmed-author:AbberleyLeeL, pubmed-author:BriggsMichael AMA, pubmed-author:ButlerSharonS, pubmed-author:CollisKatharineK, pubmed-author:DeanDavid KDK, pubmed-author:GaibaAlessandraA, pubmed-author:HeightmanTom DTD, pubmed-author:KingN PaulNP, pubmed-author:KrausHelmutH, pubmed-author:McKayFionaF, pubmed-author:MuirAlisonA, pubmed-author:SangerGarethG, pubmed-author:ShukerNicolaN, pubmed-author:SteadmanJon G AJG, pubmed-author:TakleAndrew KAK, pubmed-author:WadsworthGrahamG, pubmed-author:WinbornKimK, pubmed-author:WitheringtonJasonJ
pubmed:issnType	Electronic
pubmed:day	15
pubmed:volume	18
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	2203-5
pubmed:meshHeading	pubmed-meshheading:18316188-Administration, Oral, pubmed-meshheading:18316188-Animals, pubmed-meshheading:18316188-Biological Availability, pubmed-meshheading:18316188-Fluorescence, pubmed-meshheading:18316188-Indoles, pubmed-meshheading:18316188-Male, pubmed-meshheading:18316188-Molecular Structure, pubmed-meshheading:18316188-Rats, pubmed-meshheading:18316188-Rats, Sprague-Dawley, pubmed-meshheading:18316188-Receptor, Serotonin, 5-HT1B, pubmed-meshheading:18316188-Receptors, Ghrelin, pubmed-meshheading:18316188-Structure-Activity Relationship, pubmed-meshheading:18316188-Sulfonamides
pubmed:year	2008
pubmed:articleTitle	Potent achiral agonists of the growth hormone secretagogue (ghrelin) receptor. Part 2: Lead optimisation.
pubmed:affiliation	Department of Medicinal Chemistry & DMPK, Neurology & GI Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK. Jason_Witherington@GSK.com
pubmed:publicationType	Journal Article