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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1991-9-25
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pubmed:abstractText |
Comparative molecular field analysis (CoMFA) has been used as a three-dimensional quantitative structure-activity relationship (QSAR) method to correlate three different types of biological activity data with physicochemical properties of some clodronate ester analogues, which act as bone-resorption regulators in cell cultures and rats. The QSAR studies show the importance of the steric properties of these new bisphosphonate derivatives for the inhibition of bone resorption in bone cell cultures and for their bioavailability in rats. This information will be used in predicting the structure of new more potent bisphosphonic compounds.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-2623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2338-43
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:1831506-Animals,
pubmed-meshheading:1831506-Biological Availability,
pubmed-meshheading:1831506-Bone Resorption,
pubmed-meshheading:1831506-Bone and Bones,
pubmed-meshheading:1831506-Calcium,
pubmed-meshheading:1831506-Calcium Radioisotopes,
pubmed-meshheading:1831506-Chemistry, Physical,
pubmed-meshheading:1831506-Clodronic Acid,
pubmed-meshheading:1831506-Esters,
pubmed-meshheading:1831506-Male,
pubmed-meshheading:1831506-Mice,
pubmed-meshheading:1831506-Molecular Structure,
pubmed-meshheading:1831506-Parathyroidectomy,
pubmed-meshheading:1831506-Physicochemical Phenomena,
pubmed-meshheading:1831506-Rats,
pubmed-meshheading:1831506-Rats, Inbred Strains,
pubmed-meshheading:1831506-Structure-Activity Relationship,
pubmed-meshheading:1831506-Thyroidectomy
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pubmed:year |
1991
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pubmed:articleTitle |
Comparative molecular field analysis of some clodronic acid esters.
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pubmed:affiliation |
University of Joensuu, Department of Chemistry, Finland.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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