Source:http://linkedlifedata.com/resource/pubmed/id/18314311
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2008-3-11
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pubmed:abstractText |
The efficacy of serotonin reuptake inhibitors in depression and anxiety disorders suggests the gene coding for the serotonin transporter (5-HTT), SLC6A4, as a candidate of importance for these conditions. Positive findings regarding associations between polymorphisms in SLC6A4 have been reported, indicating that these polymorphisms may influence anxiety-related personality traits, as well as the risk of developing depression and suicidality. Serotonin 5-HTT availability was assessed with single photon emission computed tomography (SPECT), using (123)I-beta-CIT as ligand, in a population of unmedicated male suicide attempters (n=9) and in matched controls (n=9). Two polymorphisms in SLC6A4 were assessed, including the 5-HTTLPR located in the promoter region and a variable number of tandem repeats (VNTR) polymorphism in intron 2 (STin2). In suicide attempters, but not in controls, low 5-HTT availability was associated with the S allele of 5-HTTLPR and with the 12 repeat allele of STin2. Data suggest that polymorphisms in SLC6A4 may influence the expression of the brain serotonin transporter in suicide attempters.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0165-1781
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
162
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
221-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:18314311-Adult,
pubmed-meshheading:18314311-Alleles,
pubmed-meshheading:18314311-Brain,
pubmed-meshheading:18314311-Gene Expression,
pubmed-meshheading:18314311-Gene Frequency,
pubmed-meshheading:18314311-Humans,
pubmed-meshheading:18314311-Introns,
pubmed-meshheading:18314311-Male,
pubmed-meshheading:18314311-Minisatellite Repeats,
pubmed-meshheading:18314311-Polymorphism, Genetic,
pubmed-meshheading:18314311-Promoter Regions, Genetic,
pubmed-meshheading:18314311-Self-Injurious Behavior,
pubmed-meshheading:18314311-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:18314311-Suicide, Attempted,
pubmed-meshheading:18314311-Tomography, Emission-Computed, Single-Photon
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pubmed:year |
2008
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pubmed:articleTitle |
Serotonin transporter gene polymorphisms: effect on serotonin transporter availability in the brain of suicide attempters.
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pubmed:affiliation |
Department of Pharmacology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at Göteborg University, Sweden. jessica.bah@pharm.gu.se
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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