Linked Life Data

18313971

Source:http://linkedlifedata.com/resource/pubmed/id/18313971

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2008-8-25
pubmed:abstractText
The analysis of long-latency event-related potentials (ERPs) is of importance in the evaluation of certain cognitive functions and in following their subsequent changes. The aim of the present study was to investigate whether deep brain stimulation (DBS) itself can cause changes in the configuration of the ERPs. Using a standard oddball auditory paradigm, we elicited auditory cognitive ERPs in 23 Parkinson's disease patients (in both DBS-ON and DBS-OFF conditions) and in 14 healthy controls. The P200 and P300 amplitudes and latencies, the motor reaction times and the accuracy of button pressing were compared between the DBS-ON and DBS-OFF states and subsequently correlated with the applied stimulation voltage and disease duration. Comparison of the DBS-ON and DBS-OFF conditions revealed that neither the amplitude nor the latency of the examined ERP components changed significantly. However, the behavioral and attentional aspects (e.g. the accuracy of the button pressing responses to the target signal) definitely improved after the DBS was turned on. Positive correlations were demonstrated between the P300 amplitudes over the central and frontal regions and the optimal stimulation voltage and between the disease duration and P300 latencies over the Cz and Fz sites. In conclusion, our data indicate that DBS may have different impacts on various electrophysiological parameters during the oddball paradigm.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1353-8020
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
476-80
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
The impact of bilateral subthalamic deep brain stimulation on long-latency event-related potentials.
pubmed:affiliation
Department of Neurology, University of Pecs, Pecs, Hungary. norbert.kovacs@aok.pte.hu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't