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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2008-3-17
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pubmed:databankReference |
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pubmed:abstractText |
A novel structural class of p38alpha MAP kinase inhibitors has been identified via iterative SAR studies of a focused deck screen hit. Optimization of the lead series generated 6e, BMS-640994, a potent and selective p38alpha inhibitor that is orally efficacious in rodent models of acute and chronic inflammation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:BarrishJoel CJC,
pubmed-author:DoddJohnJ,
pubmed-author:DoweykoArthur MAM,
pubmed-author:GilloolyKathleen MKM,
pubmed-author:HynesJohnJJr,
pubmed-author:KieferSusan ESE,
pubmed-author:KishKevinK,
pubmed-author:LeftherisKaterinaK,
pubmed-author:MarathePunit HPH,
pubmed-author:McIntyreKim WKW,
pubmed-author:McKinnonMurrayM,
pubmed-author:NewittJohn AJA,
pubmed-author:PittSidneyS,
pubmed-author:SackJohn SJS,
pubmed-author:SchievenGary LGL,
pubmed-author:ShenDing RenDR,
pubmed-author:ShusterDavid JDJ,
pubmed-author:TaylorTracy LTL,
pubmed-author:WuHongH,
pubmed-author:YangXiaoXiaX,
pubmed-author:ZhangHongjianH,
pubmed-author:ZhangRosemaryR
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1762-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18313298-Animals,
pubmed-meshheading:18313298-Arthritis,
pubmed-meshheading:18313298-Caco-2 Cells,
pubmed-meshheading:18313298-Cell Membrane Permeability,
pubmed-meshheading:18313298-Cells, Cultured,
pubmed-meshheading:18313298-Crystallography, X-Ray,
pubmed-meshheading:18313298-Cytochrome P-450 Enzyme System,
pubmed-meshheading:18313298-Ether-A-Go-Go Potassium Channels,
pubmed-meshheading:18313298-Humans,
pubmed-meshheading:18313298-Lipopolysaccharides,
pubmed-meshheading:18313298-Male,
pubmed-meshheading:18313298-Mice,
pubmed-meshheading:18313298-Microsomes, Liver,
pubmed-meshheading:18313298-Mitogen-Activated Protein Kinase 14,
pubmed-meshheading:18313298-Molecular Structure,
pubmed-meshheading:18313298-Monocytes,
pubmed-meshheading:18313298-Protein Kinase Inhibitors,
pubmed-meshheading:18313298-Rats,
pubmed-meshheading:18313298-Rats, Inbred Lew,
pubmed-meshheading:18313298-Structure-Activity Relationship,
pubmed-meshheading:18313298-Thiazoles,
pubmed-meshheading:18313298-Tumor Necrosis Factor-alpha
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pubmed:year |
2008
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pubmed:articleTitle |
The discovery of (R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbamoyl)phenyl) thiazole-5-carboxamide (BMS-640994)-A potent and efficacious p38alpha MAP kinase inhibitor.
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pubmed:affiliation |
Bristol-Myers Squibb, Princeton, NJ 08543-4000, USA. john.hynes@bms.com
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pubmed:publicationType |
Journal Article
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