Source:http://linkedlifedata.com/resource/pubmed/id/18313295
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2008-3-17
|
| pubmed:abstractText |
A series of 1-(N-benzylamino)-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols 6a-c, 7a-c, 8a, and 9a were prepared in five steps and evaluated for their antifungal activity. The most active compound 7b was docked into a home-made 3D model of the targeted enzyme confirming the importance of Tyr118, His377, and Ser378 residues in its binding mode.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
1464-3405
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
15
|
| pubmed:volume |
18
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1820-4
|
| pubmed:meshHeading |
pubmed-meshheading:18313295-Antifungal Agents,
pubmed-meshheading:18313295-Aspergillus fumigatus,
pubmed-meshheading:18313295-Candida albicans,
pubmed-meshheading:18313295-Drug Design,
pubmed-meshheading:18313295-Microbial Sensitivity Tests,
pubmed-meshheading:18313295-Models, Molecular,
pubmed-meshheading:18313295-Propanols,
pubmed-meshheading:18313295-Structure-Activity Relationship
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Design, synthesis, and evaluation of 1-(N-benzylamino)-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents.
|
| pubmed:affiliation |
Université de Nantes, Nantes Atlantique Universités, Département de Pharmacochimie, Biomolécules et Cibles Thérapeutiques, BioCiT-EA 1155, UFR de Sciences Pharmaceutiques, 1 rue Gaston Veil, Nantes, F-44035 Cedex 1, France.
|
| pubmed:publicationType |
Journal Article,
Evaluation Studies
|