| pubmed-article:1831268 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1831268 | lifeskim:mentions | umls-concept:C0018183 | lld:lifeskim |
| pubmed-article:1831268 | lifeskim:mentions | umls-concept:C0302090 | lld:lifeskim |
| pubmed-article:1831268 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:1831268 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:1831268 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:1831268 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:1831268 | pubmed:dateCreated | 1991-9-18 | lld:pubmed |
| pubmed-article:1831268 | pubmed:abstractText | Transforming growth factor beta 1 (TGF-beta 1) is known to inhibit the growth of immature hematopoietic progenitor cells, whereas more mature, lineage-restricted progenitors are not inhibited. In contrast, in the presence of saturating concentrations of granulocyte/macrophage-colony-stimulating factor (GM-CSF), TGF-beta promoted a 3- to 5-fold increase in the number and size (greater than 0.5 mm) of bone marrow colonies in a dose-dependent manner with an ED50 of 10-20 pM; TGF-beta 1 alone had no effect. Morphological examination showed an increase in granulocyte colonies. In suspension cultures, TGF-beta 1 and GM-CSF stimulated an increase in total viable cells with markedly enhanced neutrophilic differentiation and a concomitant decrease in the number of monocytes/macrophages by day 6 in culture. Limiting dilution analysis demonstrated a 2- to 5-fold increase in the frequency of progenitor cells that responded to GM-CSF plus TGF-beta 1 vs. GM-CSF alone. Bone marrow progenitors obtained from mice 3 days after treatment with 5-fluorouracil responded to a combination of GM-CSF and TGF-beta 1, whereas either factor alone had no effect. A single-cell assay identified a progenitor cell that directly responded to TGF-beta and GM-CSF. TGF-beta increased the number of GM-CSF receptors on bone marrow cells. Thus, TGF-beta 1 can act as a bifunctional mediator of hematopoietic cell growth, and TGF-beta 1 and GM-CSF act together to stimulate granulopoiesis as measured by large granulocyte colony formation; the progenitor cell is tentatively designated granulocyte burst-forming unit. | lld:pubmed |
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| pubmed-article:1831268 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:1831268 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1831268 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1831268 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:1831268 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:1831268 | pubmed:author | pubmed-author:RuscettiF WFW | lld:pubmed |
| pubmed-article:1831268 | pubmed:author | pubmed-author:KellerJ RJR | lld:pubmed |
| pubmed-article:1831268 | pubmed:author | pubmed-author:JacobsenS ESE | lld:pubmed |
| pubmed-article:1831268 | pubmed:author | pubmed-author:EllingsworthL... | lld:pubmed |
| pubmed-article:1831268 | pubmed:author | pubmed-author:SillK TKT | lld:pubmed |
| pubmed-article:1831268 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1831268 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:1831268 | pubmed:volume | 88 | lld:pubmed |
| pubmed-article:1831268 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1831268 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1831268 | pubmed:pagination | 7190-4 | lld:pubmed |
| pubmed-article:1831268 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1831268 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1831268 | pubmed:articleTitle | Stimulation of granulopoiesis by transforming growth factor beta: synergy with granulocyte/macrophage-colony-stimulating factor. | lld:pubmed |
| pubmed-article:1831268 | pubmed:affiliation | Biological Carcinogenesis and Development Program, Program Resources, Inc., Frederick, MD. | lld:pubmed |
| pubmed-article:1831268 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1831268 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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