Linked Life Data

18312478

Source:http://linkedlifedata.com/resource/pubmed/id/18312478

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2008-4-17
pubmed:abstractText
Occasional reports have mentioned the prevalence of multiple sclerosis (MS) among Gypsies, and no studies have examined to date the prevalence of MS or human leukocyte antigen (HLA) genetics associations in the Spanish Gypsy population. We decided to study the prevalence, mitochondrial DNA (mtDNA) haplogroups and HLA class II distribution among gypsies with MS in southern Spain. We searched for Gypsy MS patients and studied HLA class II alleles by polymerase chain reaction with sequence-specific oligonucleotide (PCR/SSO) probe hybridization or sequence-specific primers amplification. An additional study of the mtDNA haplogroups by sequencing of the hypervariable segments of the control region was also performed to provide details of their ethnic origin. Estimated prevalence of MS in the Gypsy population in Malaga was 52/100,000. No significant differences were found in mtDNA between Gypsy MS patients and Gypsy controls. DRB1*1501, DQB1*0602 and DQB1*0608 alleles were the only positive HLA association with MS. The Gypsies in our series have the same anthropological origin as other European gypsy groups, as shown by mtDNA haplogroups. Although interpreted with great caution because of the small sample size, we found that the prevalence of MS in Gypsies in Malaga is not as low as that in Central Europe, although it is significantly less than that found in Caucasians from Spain (75-79/100,000). DQB1*0602 was the strongest positive association found with Gypsy MS patients, and DRB1*1501-DQB1*0602 was the most frequent haplotype in this group.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0001-2815
pubmed:author
pubmed:issnType
Print
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
426-33
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:18312478-Adolescent, pubmed-meshheading:18312478-Adult, pubmed-meshheading:18312478-Aged, pubmed-meshheading:18312478-Alleles, pubmed-meshheading:18312478-DNA, Mitochondrial, pubmed-meshheading:18312478-Female, pubmed-meshheading:18312478-Genes, MHC Class II, pubmed-meshheading:18312478-Genetic Predisposition to Disease, pubmed-meshheading:18312478-Genetics, Population, pubmed-meshheading:18312478-Gypsies, pubmed-meshheading:18312478-HLA-DQ Antigens, pubmed-meshheading:18312478-HLA-DQ beta-Chains, pubmed-meshheading:18312478-Haplotypes, pubmed-meshheading:18312478-Humans, pubmed-meshheading:18312478-Male, pubmed-meshheading:18312478-Membrane Glycoproteins, pubmed-meshheading:18312478-Middle Aged, pubmed-meshheading:18312478-Mitochondria, pubmed-meshheading:18312478-Multiple Sclerosis, pubmed-meshheading:18312478-Prevalence, pubmed-meshheading:18312478-Spain
pubmed:year
2008
pubmed:articleTitle
Multiple sclerosis in Gypsies from southern Spain: prevalence, mitochondrial DNA haplogroups and HLA class II association.
pubmed:affiliation
Institute of Clinical Neurosciences, Hospital Regional Universitario Carlos Haya, Malaga, Spain. oscar.fernandez.sspa@juntadeandalucia.es
pubmed:publicationType
Journal Article, Comparative Study