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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2008-3-3
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pubmed:abstractText |
The purpose of this study was to assess the bitterness intensity and pH of the solutions of clarithromycin dry syrup (CAM-DS), carbocisteine preparation (CC), and the concomitant use of both drugs. We conducted 6 types of human gustatory sensation tests with 6 healthy male volunteers. As a result, there was almost no difference in the bitterness intensity of CAM-DS between the branded (the latest and former preparations) and the generic formulations. The bitterness intensity of CAM-DS (the latest and former preparations of the branded as well as the generic formulations) was almost equally enhanced by mixing it with either the branded CC-DS or the branded and the generic carbocisteine granule (CC-Gr). On this occasion, the enhancing the bitterness of the branded CAM-DS (latest and former preparation) was nearly avoided safely by dosage form's changing CC-DS or CC-Gr to the branded CC-Sy. However, unlike the branded CC-Sy, some generic CC-Sy failed to suppress the bitterness. Furthermore, it was proven that some generic CAM-DS were shown to exhibit bitterness when mixed with even branded CC-Sy. In conclusion, it should be noted that the extent of bitterness of the mixture of CAM-DS and CC highly varies among the generic formulations.
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pubmed:language |
jpn
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0031-6903
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pubmed:author |
pubmed-author:AkamineYukikoY,
pubmed-author:AsadaYukiY,
pubmed-author:HoriSatokoS,
pubmed-author:IsonoKimikoK,
pubmed-author:KanouMichikoM,
pubmed-author:KinositaMasakazuM,
pubmed-author:KunokiYoshikoY,
pubmed-author:MatsuoRitsukoR,
pubmed-author:MikiAkikoA,
pubmed-author:OhtaniHisakazuH,
pubmed-author:SatohHirokiH,
pubmed-author:SawadaYasufumiY,
pubmed-author:SawaiHashimuH,
pubmed-author:SudouTomomiT,
pubmed-author:TanakaSyoukoS,
pubmed-author:TanakaYasuhaY,
pubmed-author:TauraTomokoT
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pubmed:issnType |
Print
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pubmed:volume |
128
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
479-85
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pubmed:meshHeading |
pubmed-meshheading:18311069-Anti-Bacterial Agents,
pubmed-meshheading:18311069-Carbocysteine,
pubmed-meshheading:18311069-Chemistry, Pharmaceutical,
pubmed-meshheading:18311069-Clarithromycin,
pubmed-meshheading:18311069-Dosage Forms,
pubmed-meshheading:18311069-Drug Combinations,
pubmed-meshheading:18311069-Drug Compounding,
pubmed-meshheading:18311069-Drugs, Generic,
pubmed-meshheading:18311069-Humans,
pubmed-meshheading:18311069-Hydrogen-Ion Concentration,
pubmed-meshheading:18311069-Male,
pubmed-meshheading:18311069-Taste,
pubmed-meshheading:18311069-Taste Threshold
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pubmed:year |
2008
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pubmed:articleTitle |
[Bitterness of the mixture of clarithromycin dry syrup and carbocisteine preparation--difference between brand name and generic drugs].
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pubmed:affiliation |
Incorporated Foundation of Wadoukai Pharmacy, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
English Abstract
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