Source:http://linkedlifedata.com/resource/pubmed/id/18310064
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2008-3-24
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| pubmed:abstractText |
The inducible co-stimulator (ICOS, CD278) is essential to the efficient development of normal and pathological immune reactions. Since ICOS-deficient mice have enhanced susceptibility to experimental allergic encephalomyelitis (EAE), we have functionally analyzed a CD4+ICOS+ population comprising 6-15% of all CD4+ T cells in secondary lymphoid organs of unmanipulated wild-type mice and checked for their ability to suppress EAE. In C57BL/6 mice, CD4+ICOS+ cells were a major source of cytokines including IFN-gamma, IL-2, IL-4, IL-10 or IL-17A. Upon activation, these cells showed preferentially enhanced production of IL-4 or IL-10 but inhibited IFN-gamma production. In contrast, CD4+ICOS- cells mainly produced IFN-gamma. Interestingly, CD4+ICOS+ cells partially suppressed the proliferation of CD4+ICOS- or CD4+CD25- lymphocytes 'in vitro' by an IL-10-dependent mechanism. Furthermore, CD4+ICOS+ activated and expanded under appropriate conditions yielded a population enriched in cells producing IL-10 and T(h)2 cytokines that also suppressed the proliferation of CD4+CD25- lymphocytes. CD4+ICOS+ cells, before or after expansion in vitro, reduced the severity of EAE when transferred to ICOS-deficient mice. In the same EAE model, lymph node cells from ICOS-deficient mice receiving ICOS+ cells showed reduced IL-17A production and enhanced IL-10 secretion upon antigen activation in vitro. Thus, naturally occurring CD4+ICOS+ cells, expanded or not in vitro, are functionally relevant cells able of protecting ICOS-deficient mice from severe EAE.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Icos protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Inducible T-Cell Co-Stimulator...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-17
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| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
|
| pubmed:issn |
1460-2377
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
20
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
577-89
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:18310064-Adoptive Transfer,
pubmed-meshheading:18310064-Animals,
pubmed-meshheading:18310064-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:18310064-CD4-Positive T-Lymphocytes,
pubmed-meshheading:18310064-Cell Proliferation,
pubmed-meshheading:18310064-Cells, Cultured,
pubmed-meshheading:18310064-Disease Models, Animal,
pubmed-meshheading:18310064-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:18310064-Inducible T-Cell Co-Stimulator Protein,
pubmed-meshheading:18310064-Interleukin-10,
pubmed-meshheading:18310064-Interleukin-17,
pubmed-meshheading:18310064-Lymphocyte Activation,
pubmed-meshheading:18310064-Mice,
pubmed-meshheading:18310064-Mice, Inbred BALB C,
pubmed-meshheading:18310064-Mice, Inbred C57BL,
pubmed-meshheading:18310064-Mice, Knockout,
pubmed-meshheading:18310064-T-Lymphocytes, Regulatory,
pubmed-meshheading:18310064-Th2 Cells
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| pubmed:year |
2008
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| pubmed:articleTitle |
CD4+ICOS+ T lymphocytes inhibit T cell activation 'in vitro' and attenuate autoimmune encephalitis 'in vivo'.
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| pubmed:affiliation |
Departamento de Inmunología, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu 9, E-28040 Madrid, Spain. jmrojo@cib.csic.es
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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