18309947

Source:http://linkedlifedata.com/resource/pubmed/id/18309947

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0201734, umls-concept:C0600688, umls-concept:C1135135, umls-concept:C1521761, umls-concept:C1709519
pubmed:issue	7
pubmed:dateCreated	2008-3-3
pubmed:abstractText	To assess the pharmacogenomic and pharmacokinetic determinants of skin rash and diarrhea, the two primary dose-limiting toxicities of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/GM61393, http://linkedlifedata.com/resource/pubmed/grant/P30 CA14599, http://linkedlifedata.com/resource/pubmed/grant/R21 CA10132, http://linkedlifedata.com/resource/pubmed/grant/U01 CA69852
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8309333
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/ABCG2 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/ATP-Binding Cassette Transporters, http://linkedlifedata.com/resource/pubmed/chemical/CYP3A4 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/CYP3A5 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP3A, http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System, http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Quinazolines, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor, http://linkedlifedata.com/resource/pubmed/chemical/erlotinib
pubmed:status	MEDLINE
pubmed:month	Mar
pubmed:issn	1527-7755
pubmed:author	pubmed-author:ArmstrongDeborah KDK, pubmed-author:BalasubramanianPoonkuzhaliP, pubmed-author:BrahmerJulie RJR, pubmed-author:CarducciMichael AMA, pubmed-author:ChenPeixianP, pubmed-author:DasSomaS, pubmed-author:DesaiApurvaA, pubmed-author:FackenthalDonna LeeDL, pubmed-author:FlemingGini FGF, pubmed-author:JanischLindaL, pubmed-author:JiangXueminX, pubmed-author:KarrisonTheodoreT, pubmed-author:LiuWanqingW, pubmed-author:RamirezJacquelineJ, pubmed-author:RatainMark JMJ, pubmed-author:RudinCharles MCM, pubmed-author:SchuetzErinE, pubmed-author:VokesEverett EEE
pubmed:issnType	Electronic
pubmed:day	1
pubmed:volume	26
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1119-27
pubmed:dateRevised	2009-11-19
pubmed:meshHeading	pubmed-meshheading:18309947-ATP-Binding Cassette Transporters, pubmed-meshheading:18309947-Adult, pubmed-meshheading:18309947-Aged, pubmed-meshheading:18309947-Aged, 80 and over, pubmed-meshheading:18309947-Carcinoma, Non-Small-Cell Lung, pubmed-meshheading:18309947-Cytochrome P-450 CYP3A, pubmed-meshheading:18309947-Cytochrome P-450 Enzyme System, pubmed-meshheading:18309947-Diarrhea, pubmed-meshheading:18309947-Exanthema, pubmed-meshheading:18309947-Female, pubmed-meshheading:18309947-Head and Neck Neoplasms, pubmed-meshheading:18309947-Humans, pubmed-meshheading:18309947-Lung Neoplasms, pubmed-meshheading:18309947-Male, pubmed-meshheading:18309947-Middle Aged, pubmed-meshheading:18309947-Neoplasm Proteins, pubmed-meshheading:18309947-Neoplasms, Squamous Cell, pubmed-meshheading:18309947-Ovarian Neoplasms, pubmed-meshheading:18309947-Pharmacogenetics, pubmed-meshheading:18309947-Polymorphism, Genetic, pubmed-meshheading:18309947-Prospective Studies, pubmed-meshheading:18309947-Protein Kinase Inhibitors, pubmed-meshheading:18309947-Quinazolines, pubmed-meshheading:18309947-Receptor, Epidermal Growth Factor
pubmed:year	2008
pubmed:articleTitle	Pharmacogenomic and pharmacokinetic determinants of erlotinib toxicity.
pubmed:affiliation	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, David H. Koch Cancer Research Building, Room 544, 1550 Orleans St, Baltimore, MD 21231, USA. rudin@jhmi.edu
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't, Multicenter Study, Research Support, N.I.H., Extramural