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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2008-3-25
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pubmed:abstractText |
Insulin-like growth factor I (IGF-1) is a pleiotropic growth factor that has been demonstrated to protect against acute ischemic brain injury. Whether IGF-1 improves long-term functional outcome after ischemic stroke is not known. The aim of this study is to examine whether IGF-1 overexpression through adeno-associated virus (AAV) -mediated gene transfer enhances neurovascular remodeling and improves functional outcome in a mouse model of focal cerebral ischemia.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18309153-11252770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18309153-11333359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18309153-11340238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18309153-11440750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18309153-12100987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18309153-12813020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18309153-1313498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18309153-14526226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18309153-14535942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18309153-15210967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18309153-15336580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18309153-15472070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18309153-15477425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18309153-15668145,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18309153-15678110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18309153-15678129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18309153-15879695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18309153-16000060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18309153-16144956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18309153-16467542,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18309153-16882007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18309153-1689322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18309153-16946160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18309153-17038638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18309153-17167090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18309153-7100929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18309153-9114067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18309153-9465113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18309153-9500961
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1524-4628
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1254-61
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18309153-Animals,
pubmed-meshheading:18309153-Atrophy,
pubmed-meshheading:18309153-Cell Division,
pubmed-meshheading:18309153-Cerebrovascular Circulation,
pubmed-meshheading:18309153-Dependovirus,
pubmed-meshheading:18309153-Disease Models, Animal,
pubmed-meshheading:18309153-Gene Therapy,
pubmed-meshheading:18309153-Infarction, Middle Cerebral Artery,
pubmed-meshheading:18309153-Insulin-Like Growth Factor I,
pubmed-meshheading:18309153-Mice,
pubmed-meshheading:18309153-Mice, Inbred Strains,
pubmed-meshheading:18309153-Neovascularization, Physiologic,
pubmed-meshheading:18309153-Neurons,
pubmed-meshheading:18309153-Recovery of Function,
pubmed-meshheading:18309153-Transduction, Genetic
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pubmed:year |
2008
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pubmed:articleTitle |
Insulin growth factor-1 gene transfer enhances neurovascular remodeling and improves long-term stroke outcome in mice.
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pubmed:affiliation |
Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California San Francisco, San Francisco,CA 94110, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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