Linked Life Data

1830846

Source:http://linkedlifedata.com/resource/pubmed/id/1830846

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
1991-9-10
pubmed:abstractText
Emodin and scoparone, the active principles isolated from Polygonum multiflorum and Artemisia scoparia, respectively, both exhibit vasorelaxant and immunosuppressive effects. Emodin (10(-6)-3 x 10(-5) M) and scoparone (10(-6)-3 x 10(-5) M) dose dependently relaxed rat thoracic aortic rings precontracted with phenylephrine. Emodin (3 x 10(-7)-10(-4) M) and scoparone (10(-6)-3 x 10(-4) M) also dose dependently suppressed the responses of human mononuclear cells to phytohemagglutinin and mixed lymphocyte reaction. These compounds may be useful as new templates for the development of better immunosuppressive agents with vasorelaxant actions for use against transplantation rejection and autoimmune disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
6
pubmed:volume
198
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
211-3
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Vasorelaxants from Chinese herbs, emodin and scoparone, possess immunosuppressive properties.
pubmed:affiliation
Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, R.O.C.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't