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rdf:type |
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lifeskim:mentions |
umls-concept:C0011854,
umls-concept:C0011900,
umls-concept:C0085358,
umls-concept:C0087111,
umls-concept:C0376249,
umls-concept:C0392747,
umls-concept:C0871261,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1704632,
umls-concept:C1706438,
umls-concept:C1706817,
umls-concept:C2698600,
umls-concept:C2911692
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pubmed:issue |
5
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pubmed:dateCreated |
2008-4-29
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pubmed:abstractText |
Islet-reactive CD8(+) T-cells play a key role in the pathogenesis of type 1 diabetes in the NOD mouse. The predominant T-cell specificities change over time, but whether similar shifts also occur after clinical diagnosis and insulin treatment in type 1 diabetic patients is unknown.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1939-327X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1312-20
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18305140-Adolescent,
pubmed-meshheading:18305140-Adult,
pubmed-meshheading:18305140-Animals,
pubmed-meshheading:18305140-CD8-Positive T-Lymphocytes,
pubmed-meshheading:18305140-Coxsackievirus Infections,
pubmed-meshheading:18305140-Diabetes Mellitus, Type 1,
pubmed-meshheading:18305140-Disease Models, Animal,
pubmed-meshheading:18305140-Epitopes,
pubmed-meshheading:18305140-Glucose-6-Phosphatase,
pubmed-meshheading:18305140-Glutamate Decarboxylase,
pubmed-meshheading:18305140-HLA-A2 Antigen,
pubmed-meshheading:18305140-Humans,
pubmed-meshheading:18305140-Insulin,
pubmed-meshheading:18305140-Insulin-Secreting Cells,
pubmed-meshheading:18305140-Islets of Langerhans,
pubmed-meshheading:18305140-Mice,
pubmed-meshheading:18305140-Mice, Inbred NOD,
pubmed-meshheading:18305140-Protein Precursors,
pubmed-meshheading:18305140-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:18305140-T-Lymphocytes, Regulatory
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pubmed:year |
2008
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pubmed:articleTitle |
The frequency and immunodominance of islet-specific CD8+ T-cell responses change after type 1 diabetes diagnosis and treatment.
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pubmed:affiliation |
INSERM U580, Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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