|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0007600,
umls-concept:C0017262,
umls-concept:C0038952,
umls-concept:C0185117,
umls-concept:C0205210,
umls-concept:C0684249,
umls-concept:C0851285,
umls-concept:C0871261,
umls-concept:C1101610,
umls-concept:C1122962,
umls-concept:C1414313,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1707520,
umls-concept:C2911684,
umls-concept:C2911692
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2008-5-29
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|
pubmed:abstractText |
Allelic loss in chromosome 3p is one of the most frequent and earliest genetic events in lung carcinogenesis. We investigated if the loss of microRNA-128b, a microRNA located on chromosome 3p and a putative regulator of epidermal growth factor receptor (EGFR), correlated with response to targeted EGFR inhibition. Loss of microRNA-128b would be equivalent to losing a tumor suppressor gene because it would allow increased expression of EGFR.
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pubmed:grant |
|
|
pubmed:commentsCorrections |
|
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pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
1569-8041
|
|
pubmed:author |
pubmed-author:BelloM KMK,
pubmed-author:BirksD KDK,
pubmed-author:BunnP APAJr,
pubmed-author:FranklinW AWA,
pubmed-author:HaneyJJ,
pubmed-author:HelfrichB ABA,
pubmed-author:HirschF RFR,
pubmed-author:KatzEE,
pubmed-author:NakajimaEE,
pubmed-author:RobinsonW AWA,
pubmed-author:SugitaMM,
pubmed-author:Varella-GarciaMM,
pubmed-author:WeissG JGJ
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|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
19
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1053-9
|
|
pubmed:meshHeading |
pubmed-meshheading:18304967-Antineoplastic Agents,
pubmed-meshheading:18304967-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:18304967-Cell Line, Tumor,
pubmed-meshheading:18304967-Gene Expression,
pubmed-meshheading:18304967-Genes, erbB-1,
pubmed-meshheading:18304967-Humans,
pubmed-meshheading:18304967-Lung Neoplasms,
pubmed-meshheading:18304967-MicroRNAs,
pubmed-meshheading:18304967-Quinazolines,
pubmed-meshheading:18304967-Survival Analysis
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|
pubmed:year |
2008
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|
pubmed:articleTitle |
EGFR regulation by microRNA in lung cancer: correlation with clinical response and survival to gefitinib and EGFR expression in cell lines.
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|
pubmed:affiliation |
TGen Clinical Research Services at Scottsdale Healthcare, Scottsdale, AZ, USA. gweiss@tgen.org
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|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|
