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rdf:type |
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lifeskim:mentions |
umls-concept:C0003320,
umls-concept:C0007634,
umls-concept:C0011854,
umls-concept:C0011900,
umls-concept:C0085295,
umls-concept:C0205369,
umls-concept:C0301872,
umls-concept:C0681842,
umls-concept:C1332714,
umls-concept:C1334114,
umls-concept:C1416467,
umls-concept:C2587213
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pubmed:issue |
2
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pubmed:dateCreated |
2008-4-14
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pubmed:abstractText |
The immune phenotype of the partial remission phase or "honeymoon phase" of type 1 diabetes is not well defined. We compared flow cytometry and cytokine production by ELISPOT assays in children with newly diagnosed type 1 diabetes and children in the partial remission phase of type 1 diabetes. Newly diagnosed children had higher levels of FoxP3 expression in CD4 CD25 double positive cells (56.1%+/-24.9 vs. 24.9%+/-24.6 p=0.03) and higher mean numbers of IL-10 producing cells (7.3 cells/2x10(5) cells+/-6.6 vs. 0.86 cells/2x10(5)+/-0.36 p=0.0043) compared to partial remission patients. Higher FoxP3 expression at diagnosis predicted worse future glycemic control while higher mean numbers of IL-10 cells were associated with better future glucose control. These data provide an immune phenotype of the honeymoon phase and suggest that analyzing IL-10 and FoxP3 at diagnosis may identify patients that will experience better glucose control.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes, T-Lymphocyte,
http://linkedlifedata.com/resource/pubmed/chemical/FOXP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Forkhead Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Hemoglobin A, Glycosylated,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2 Receptor alpha Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, TNF-Related...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor...,
http://linkedlifedata.com/resource/pubmed/chemical/hemoglobin A1c protein, human
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1521-7035
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
127
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
138-43
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18304876-Adolescent,
pubmed-meshheading:18304876-Blood Glucose,
pubmed-meshheading:18304876-CD4-Positive T-Lymphocytes,
pubmed-meshheading:18304876-Child,
pubmed-meshheading:18304876-Cross-Sectional Studies,
pubmed-meshheading:18304876-Diabetes Mellitus, Type 1,
pubmed-meshheading:18304876-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:18304876-Epitopes, T-Lymphocyte,
pubmed-meshheading:18304876-Flow Cytometry,
pubmed-meshheading:18304876-Forkhead Transcription Factors,
pubmed-meshheading:18304876-Hemoglobin A, Glycosylated,
pubmed-meshheading:18304876-Humans,
pubmed-meshheading:18304876-Insulin,
pubmed-meshheading:18304876-Interleukin-10,
pubmed-meshheading:18304876-Interleukin-2 Receptor alpha Subunit,
pubmed-meshheading:18304876-Predictive Value of Tests,
pubmed-meshheading:18304876-Receptors, TNF-Related Apoptosis-Inducing Ligand,
pubmed-meshheading:18304876-Receptors, Tumor Necrosis Factor, Member 25
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pubmed:year |
2008
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pubmed:articleTitle |
Islet antigen specific IL-10+ immune responses but not CD4+CD25+FoxP3+ cells at diagnosis predict glycemic control in type 1 diabetes.
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pubmed:affiliation |
Benaroya Research Institute and the University of Washington School of Medicine, 1201 9th Avenue, Seattle, WA 98101, USA. ssanda@benaroyaresearch.org
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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