Linked Life Data

18304820

Source:http://linkedlifedata.com/resource/pubmed/id/18304820

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2008-4-14
pubmed:abstractText
Lactenediynes are compounds characterized by the fusion of a beta-lactam with a cyclodeca-3-ene-1,5-diyne. In this work the most promising members of this family have been activated by attaching a carbalkoxy or a carbamoyl group to the azetidinone nitrogen, and conjugated to various DNA-complexing moieties, either acting by intercalation or through groove binding. These conjugated artificial enediynes have been demonstrated to possess in vitro ability to produce single and double strand cleavage of plasmid DNA. As potency and capacity to induce double cut, they rank among the best simple enediyne analogues ever prepared. A thorough investigation was carried out in order to develop the best suited linkers for assembling these conjugates.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1464-3391
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3501-18
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Synthesis and DNA-cleaving activity of lactenediynes conjugated with DNA-complexing moieties.
pubmed:affiliation
Dipartimento di Chimica e Chimica Industriale, via Dodecaneso 31, I-16146 Genova, Italy. banfi@chimica.unige.it
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't