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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2008-3-24
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pubmed:abstractText |
The Gram-negative bacterium Pseudomonas aeruginosa, an opportunistic human pathogen, uses acyl-homoserine lactone-based quorum sensing systems to control its pathogenicity. One of its quorum sensing factors, N-3-oxo-dodecanoyl-homoserine lactone, has been shown not only to mediate bacterial quorum sensing but also to exert cytotoxic effects on mammalian cells. The monoclonal antibody RS2-1G9 generated against a 3-oxo-dodecanoyl-homoserine lactone analogue hapten was able to protect murine bone marrow-derived macrophages from the cytotoxic effects and also prevented the activation of the mitogen-activated protein kinase p38. These data demonstrate that an immunopharmacotherapeutic approach to combat P. aeruginosa infections might be a viable therapeutic option as the monoclonal antibody RS2-1G9 can readily sequester bacterial N-3-oxo-dodecanoyl-homoserine lactone molecules, thus interfering with their biological effects in prokaryotic and eukaryotic systems.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18304641-11807074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18304641-12177434,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18304641-9848438
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0161-5890
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2710-4
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pubmed:dateRevised |
2010-12-3
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pubmed:meshHeading |
pubmed-meshheading:18304641-4-Butyrolactone,
pubmed-meshheading:18304641-Animals,
pubmed-meshheading:18304641-Antibodies, Monoclonal,
pubmed-meshheading:18304641-Cell Line,
pubmed-meshheading:18304641-Cells, Cultured,
pubmed-meshheading:18304641-Enzyme Activation,
pubmed-meshheading:18304641-Haptens,
pubmed-meshheading:18304641-Homoserine,
pubmed-meshheading:18304641-Macrophages,
pubmed-meshheading:18304641-Mice,
pubmed-meshheading:18304641-Poly(ADP-ribose) Polymerases,
pubmed-meshheading:18304641-Pseudomonas aeruginosa,
pubmed-meshheading:18304641-Quorum Sensing,
pubmed-meshheading:18304641-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2008
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pubmed:articleTitle |
The quorum quenching antibody RS2-1G9 protects macrophages from the cytotoxic effects of the Pseudomonas aeruginosa quorum sensing signalling molecule N-3-oxo-dodecanoyl-homoserine lactone.
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pubmed:affiliation |
Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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