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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2008-3-5
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pubmed:abstractText |
Lumbar-disc degeneration (LDD) is a polygenic disease. Susceptibility genes reported so far are mainly extracellular matrix proteins. D14 allele of asporin (ASPN) is associated with osteoarthritis (OA). Candidate-gene association studies showed that the D14 allele is also significantly associated with LDD in Chinese and Japanese individuals. Meta-analysis showed that individuals harboring a D14 allele had higher risk with a summary odds ratio of 1.70 (p = 0.000013). ASPN expression in vertebral discs increased with age and degeneration. Our results indicate ASPN is a LDD gene in Asians, and common risk factors may be considered for OA and LDD.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18304494-10025932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18304494-10411504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18304494-10470716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18304494-10626307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18304494-11152692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18304494-11308397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18304494-15640800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18304494-15864306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18304494-16371896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18304494-17038197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18304494-17195216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18304494-17220213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18304494-17517696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18304494-17827158,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18304494-2954224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18304494-8747238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18304494-9589542
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1537-6605
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pubmed:author |
pubmed-author:AliniMauroM,
pubmed-author:ChanDannyD,
pubmed-author:CheahKathryn S EKS,
pubmed-author:CheungKenneth M CKM,
pubmed-author:ChibaKazuhiroK,
pubmed-author:GradSibylleS,
pubmed-author:HiroseYuichiroY,
pubmed-author:HoDaniel W HDW,
pubmed-author:IkegawaShiroS,
pubmed-author:KarppinenJaroJ,
pubmed-author:KawaguchiYoshiharuY,
pubmed-author:LeongJohn C YJC,
pubmed-author:LukKeith D KKD,
pubmed-author:PoonSandy C SSC,
pubmed-author:ShamPakP,
pubmed-author:SongYou-QiangYQ,
pubmed-author:YeeAnita F YAF,
pubmed-author:YipShea-PingSP
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pubmed:issnType |
Electronic
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
744-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18304494-Adolescent,
pubmed-meshheading:18304494-Adult,
pubmed-meshheading:18304494-Alleles,
pubmed-meshheading:18304494-Asian Continental Ancestry Group,
pubmed-meshheading:18304494-Aspartic Acid,
pubmed-meshheading:18304494-Extracellular Matrix Proteins,
pubmed-meshheading:18304494-Female,
pubmed-meshheading:18304494-Gene Frequency,
pubmed-meshheading:18304494-Genetic Predisposition to Disease,
pubmed-meshheading:18304494-Humans,
pubmed-meshheading:18304494-Intervertebral Disc,
pubmed-meshheading:18304494-Lumbar Vertebrae,
pubmed-meshheading:18304494-Male,
pubmed-meshheading:18304494-Middle Aged,
pubmed-meshheading:18304494-Osteoarthritis,
pubmed-meshheading:18304494-Osteochondritis,
pubmed-meshheading:18304494-Polymorphism, Genetic,
pubmed-meshheading:18304494-Repetitive Sequences, Amino Acid
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pubmed:year |
2008
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pubmed:articleTitle |
Association of the asporin D14 allele with lumbar-disc degeneration in Asians.
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pubmed:affiliation |
Department of Biochemistry, The University of Hong Kong, Pokfulam, Hong Kong, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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