Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-2-27
pubmed:abstractText
This study was undertaken to investigate age-dependent and postmenopausal changes in the serum levels of anti-Mullerian hormone (AMH), inhibin B, insulin-like growth factor (IGF)-I, IGF-binding protein-3 (IGFBP-3), and follicle-stimulating hormone (FSH), and to determine which of these markers best reflects the aging process in women. A total of 144 women aged 20-59 yr were enrolled in this cross-sectional study. Blood samples were obtained on cycle day 3 of regularly menstruating women (n=111), or at random in postmenopausal women (n=33). Data were analyzed with respect to premenopausal women age groups and compared in pre- and postmenopausal women. Area under the receiver operating characteristic curve (ROCAUC) analyses were performed to assess the ability of each marker to discriminate between the pre- and postmenopausal status. Serum levels of AMH, IGF-I, and IGFBP-3 decreased and serum levels of FSH increased significantly with age in premenopausal women. Serum luteinizing hormone (LH) was higher and inhibin B was lower in women in their 20-30's than in 40's. Serum levels of AMH and IGF-I showed a consistent decrease with all age groups. ROCAUC analysis showed that the diagnostic accuracy of AMH for menopausal status was similar to those of FSH, LH, and inhibin B, and was better than that of IGF-I. In conclusion, the serum AMH level appears to be the best marker of the aging process in premenopausal women.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18303208-10566644, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303208-10696567, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303208-10782364, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303208-11821097, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303208-12416998, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303208-12571168, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303208-1379166, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303208-1548349, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303208-15820810, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303208-1692331, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303208-2120380, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303208-2123449, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303208-2911937, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303208-3135465, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303208-3141454, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303208-3203132, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303208-3755843, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303208-7194884, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303208-7684393, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303208-7758431, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303208-8137971, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303208-8167237, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303208-8625923, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303208-8675606, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303208-8706629, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303208-8729523, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303208-9531887, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303208-9688368, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303208-9866066, http://linkedlifedata.com/resource/pubmed/commentcorrection/18303208-9920069
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1011-8934
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
104-10
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Analysis of serum levels of anti-Mullerian hormone, inhibin B, insulin-like growth factor-I, insulin-like growth factor binding protein-3, and follicle-stimulating hormone with respect to age and menopausal status.
pubmed:affiliation
Department of Nuclear Medicine, College of Medicine, Seoul National University, Seoul, Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't