Linked Life Data

18302424

Source:http://linkedlifedata.com/resource/pubmed/id/18302424

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2008-3-25
pubmed:abstractText
A novel method has been developed for preparing nanogels with a lysozyme core and dextran shell. The method involves the Maillard dry-heat process and heat-gelation process. First, lysozyme-dextran conjugates were produced through the Maillard reaction. Then, the conjugate solution was heated above the denaturation temperature of lysozyme to produce nanogels. The nanogels are of spherical shape having a hydrodynamic diameter of about 200 nm and swelling ratio of about 30. The nanogel solutions are stable against long-term storage as well as changes in pH and ionic strength. Ibuprofen has been used as a drug model to study the electrostatic and hydrophobic interactions with these nanogels at different pH values. The study reveals that the nanogels are more suitable for loading protonated ibuprofen. We have verified that the knowledge of the formation mechanism of lysozyme-dextran nanogels can be applied to prepare other globular protein-dextran nanogels.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0743-7463
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3486-92
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Lysozyme-dextran core-shell nanogels prepared via a green process.
pubmed:affiliation
The Key Laboratory of Molecular Engineering of Polymer and Department of Macromolecular Science, Fudan University, Shanghai 200433, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't