Linked Life Data

18300859

Source:http://linkedlifedata.com/resource/pubmed/id/18300859

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-2-27
pubmed:abstractText
Prednisone and its active metabolite prednisolone, both substrates for 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2), may represent a pharmacological challenge for the enzyme. The aim of the present work was to define the possible role of abnormal cortisol/cortisone handling, as revealed by an urinary tetrahydrocortisol + allotetrahydrocortisol (THFs)/tetrahydrocortisone (THE) ratio between 1.5 and 3.0, by measuring urinary cortisol and cortisone metabolites in: normotensive individuals (n = 100) who received 7-8 mg/day of oral prednisone and were then followed for development of hypertension; essential hypertensive (EH) participants from primary care (n = 103); and EH hypertensive patients referred to the Hypertension Unit (n = 141).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0263-6352
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
486-93
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Urinary cortisol to cortisone metabolites ratio in prednisone-treated and spontaneously hypertensive patients.
pubmed:affiliation
Unit of Internal Medicine, Department of Clinical and Experimental Medicine, University of Verona, Italy. oliviero.olivieri@univr.it
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't