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pubmed-article:18300568pubmed:abstractTextThe presence of anti-cyclic citrullinated peptide autoantibody is highly specific for rheumatoid arthritis. Certain HLA-DR4 (HLA-DRB1*04) alleles, also known as the "shared epitope," are associated with increased susceptibility to RA. In addition, these alleles may also have relevance for disease outcome. Anti-CCP antibody positivity has been associated with the presence of HLA-DR4 alleles in patients with RA. However, there is little information regarding a relationship between quantitative anti-CCP production (serum anti-CCP concentrations) and the shared epitope.lld:pubmed
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pubmed-article:18300568pubmed:articleTitleAssociations between serum anti-CCP antibody, rheumatoid factor levels and HLA-DR4 expression in Hungarian patients with rheumatoid arthritis.lld:pubmed
pubmed-article:18300568pubmed:affiliationLaboratory of Immunology, Third Department of Medicine, University of Debrecen Medical Centre, Debrecen, Hungary.lld:pubmed
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