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rdf:type |
|
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lifeskim:mentions |
umls-concept:C0003241,
umls-concept:C0003873,
umls-concept:C0004083,
umls-concept:C0017262,
umls-concept:C0019774,
umls-concept:C0020173,
umls-concept:C0030705,
umls-concept:C0035448,
umls-concept:C0185117,
umls-concept:C0229671,
umls-concept:C0441889,
umls-concept:C2911684
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|
pubmed:issue |
1
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|
pubmed:dateCreated |
2008-2-27
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|
pubmed:abstractText |
The presence of anti-cyclic citrullinated peptide autoantibody is highly specific for rheumatoid arthritis. Certain HLA-DR4 (HLA-DRB1*04) alleles, also known as the "shared epitope," are associated with increased susceptibility to RA. In addition, these alleles may also have relevance for disease outcome. Anti-CCP antibody positivity has been associated with the presence of HLA-DR4 alleles in patients with RA. However, there is little information regarding a relationship between quantitative anti-CCP production (serum anti-CCP concentrations) and the shared epitope.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1565-1088
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
10
|
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
32-6
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pubmed:meshHeading |
pubmed-meshheading:18300568-Adolescent,
pubmed-meshheading:18300568-Adult,
pubmed-meshheading:18300568-Aged,
pubmed-meshheading:18300568-Aged, 80 and over,
pubmed-meshheading:18300568-Alleles,
pubmed-meshheading:18300568-Arthritis, Rheumatoid,
pubmed-meshheading:18300568-Autoantibodies,
pubmed-meshheading:18300568-C-Reactive Protein,
pubmed-meshheading:18300568-Disease Progression,
pubmed-meshheading:18300568-Female,
pubmed-meshheading:18300568-Gene Expression,
pubmed-meshheading:18300568-Genotype,
pubmed-meshheading:18300568-HLA-DR4 Antigen,
pubmed-meshheading:18300568-Humans,
pubmed-meshheading:18300568-Male,
pubmed-meshheading:18300568-Middle Aged,
pubmed-meshheading:18300568-Peptides, Cyclic,
pubmed-meshheading:18300568-Rheumatoid Factor
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pubmed:year |
2008
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pubmed:articleTitle |
Associations between serum anti-CCP antibody, rheumatoid factor levels and HLA-DR4 expression in Hungarian patients with rheumatoid arthritis.
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pubmed:affiliation |
Laboratory of Immunology, Third Department of Medicine, University of Debrecen Medical Centre, Debrecen, Hungary.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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