rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2008-2-26
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pubmed:abstractText |
Idiopathic adult-onset primary dystonia usually affects the upper body and remains focal. Underlying mechanisms are unknown, and there are only limited neuropathologic studies in the literature. Recently, ubiquitinated perinuclear inclusion bodies were found in the brainstem of patients with DYT1-related dystonia. In X-linked recessive dystonia-parkinsonism, neuronal loss in the striosome compartment of the striatum has been described. However, it was unclear whether these changes are characteristic of these particular disorders or an epiphenomenon of dystonic conditions in general.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
AIM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
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pubmed:month |
Feb
|
pubmed:issn |
1526-632X
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pubmed:author |
pubmed-author:BarrettMM,
pubmed-author:BhatiaK PKP,
pubmed-author:GHOLMYA HAH,
pubmed-author:GandhiSS,
pubmed-author:GanesharajahTT,
pubmed-author:HoltonJ LJL,
pubmed-author:LeesA JAJ,
pubmed-author:ReveszTT,
pubmed-author:ShashidharanPP,
pubmed-author:StrandCC,
pubmed-author:WinnR HRH
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pubmed:issnType |
Electronic
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pubmed:day |
26
|
pubmed:volume |
70
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
695-9
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pubmed:meshHeading |
pubmed-meshheading:18299520-Adult,
pubmed-meshheading:18299520-Aged,
pubmed-meshheading:18299520-Aged, 80 and over,
pubmed-meshheading:18299520-Brain Stem,
pubmed-meshheading:18299520-Corpus Striatum,
pubmed-meshheading:18299520-Dystonic Disorders,
pubmed-meshheading:18299520-Female,
pubmed-meshheading:18299520-Humans,
pubmed-meshheading:18299520-Immunoenzyme Techniques,
pubmed-meshheading:18299520-Inclusion Bodies,
pubmed-meshheading:18299520-Laminin,
pubmed-meshheading:18299520-Male,
pubmed-meshheading:18299520-Molecular Chaperones,
pubmed-meshheading:18299520-Ubiquitin
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pubmed:year |
2008
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pubmed:articleTitle |
Neuropathology of primary adult-onset dystonia.
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pubmed:affiliation |
Queen Square Brain Bank, Department of Molecular Neuroscience, University College London Institute of Neurology, Queen Square, London WC1N 3BG, UK. j.holton@ion.ucl.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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