rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
5
|
pubmed:dateCreated |
2008-4-25
|
pubmed:abstractText |
SPK-843, a new polyene antifungal, exhibited dose-dependent efficacy on murine pulmonary aspergillosis models. SPK-843 doses of higher than 1.0 mg/kg of body weight exhibited no renal toxicities and a tendency toward better survival prolongation than the estimated maximum tolerated doses of amphotericin B (Fungizone) (1.0 mg/kg) and liposomal amphotericin B (AmBisome) (8.0 mg/kg).
|
pubmed:commentsCorrections |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
1098-6596
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:volume |
52
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1868-70
|
pubmed:dateRevised |
2009-11-18
|
pubmed:meshHeading |
pubmed-meshheading:18299412-Amphotericin B,
pubmed-meshheading:18299412-Animals,
pubmed-meshheading:18299412-Antifungal Agents,
pubmed-meshheading:18299412-Aspergillosis,
pubmed-meshheading:18299412-Aspergillus flavus,
pubmed-meshheading:18299412-Disease Models, Animal,
pubmed-meshheading:18299412-Dose-Response Relationship, Drug,
pubmed-meshheading:18299412-Echinocandins,
pubmed-meshheading:18299412-Lipopeptides,
pubmed-meshheading:18299412-Lipoproteins,
pubmed-meshheading:18299412-Lung Diseases, Fungal,
pubmed-meshheading:18299412-Male,
pubmed-meshheading:18299412-Mice,
pubmed-meshheading:18299412-Polyenes,
pubmed-meshheading:18299412-Treatment Outcome
|
pubmed:year |
2008
|
pubmed:articleTitle |
Efficacy of SPK-843, a novel polyene antifungal, in comparison with amphotericin B, liposomal amphotericin B, and micafungin against murine pulmonary aspergillosis.
|
pubmed:affiliation |
Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. kakeya@nagasaki-u.ac.jp
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pubmed:publicationType |
Journal Article,
Comparative Study
|